Common variants associated with plasma triglycerides and risk for coronary artery disease

Do, R.; Willer, C.J.; Schmidt, E.M.; Sengupta, S.; Gao, C.; Peloso, G.M.; Gustafsson, S.; Kanoni, S.; Ganna, A.; Chen, J.; Buchkovich, M.L.; Mora, S.; Beckmann, J.S.; Bragg Gresham, J.L.; Chang, H.; Demirkan, A.; Den Hertog, H.M.; Donnelly, L.A.; Ehret, G.B.; Esko, T.; Feitosa, M.F.; Ferreira, T.; Fischer, K.; Fontanillas, P.; Fraser, R.M.; Freitag, D.F.; Gurdasani, D.; Heikkilä, K.; Hyppönen, E.; Isaacs, A.; Jackson, A.U.; Johansson, A.; Johnson, T.; Kaakinen, M.; Kettunen, J.; Kleber, M.E.; Li, X.; Luan, J.; Lyytikäinen, L.; Magnusson, P.K.E.; Mangino, M.; Mihailov, E.; Montasser, M.E.; Müller Nurasyid, M.; Nolte, I.M.; O'Connell, J.R.; Palmer, C.D.; Perola, M.; Petersen, A.; Sanna, S.; Saxena, R.; Service, S.K.; Shah, S.; Shungin, D.; Sidore, C.; Song, C.; Strawbridge, R.J.; Surakka, I.; Tanaka, T.; Teslovich, T.M.; Thorleifsson, G.; Van den Herik, E.G.; Voight, B.F.; Volcik, K.A.; Waite, L.L.; Wong, A.; Wu, Y.; Zhang, W.; Absher, D.; Asiki, G.; Barroso, I.; Been, L.F.; Bolton, J.L.; Bonnycastle, L.L.; Brambilla, P.; Burnett, M.S.; Cesana, G.; Dimitriou, M.; Doney, A.S.F.; Döring, A.; Elliott, P.; Epstein, S.E.; Eyjolfsson, G.I.; Gigante, B.; Goodarzi, M.O.; Grallert, H.; Gravito, M.L.; Groves, C.J.; Hallmans, G.; Hartikainen, A.; Hayward, C.; Hernandez, D.; Hicks, A.A.; Holm, H.; Hung, Y.; Illig, T.; Jones, M.R.; Kaleebu, P.; Kastelein, J.J.P.; Khaw, K.; Kim, E.; Klopp, N.; Komulainen, P.; Kumari, M.; Langenberg, C.; Lehtimäki, T.; Lin, S.; Lindström, J.; Loos, R.J.F.; Mach, F.; Mcardle, W.L.; Meisinger, C.; Mitchell, B.D.; Müller, G.; Nagaraja, R.; Narisu, N.; Nieminen, T.V.M.; Nsubuga, R.N.; Olafsson, I.; Ong, K.K.; Palotie, A.; Papamarkou, T.; Pomilla, C.; Pouta, A.; Rader, D.J.; Reilly, M.P.; Ridker, P.M.; Rivadeneira, F.; Rudan, I.; Ruokonen, A.; Samani, N.; Scharnagl, H.; Seeley, J.; Silander, K.; Stančáková, A.; Stirrups, K.; Swift, A.J.; Tiret, L.; Uitterlinden, A.G.; van Pelt, L.J.; Vedantam, S.; Wainwright, N.; Wijmenga, C.; Wild, S.H.; Willemsen, G.; Wilsgaard, T.; Wilson, J.F.; Young, E.H.; Zhao, J.H.; Adair, L.S.; Arveiler, D.; Assimes, T.L.; Bandinelli, S.; Bennett, F.; Bochud, M.; Boehm, B.O.; Boomsma, D.I.; Borecki, I.B.; Bornstein, S.R.; Bovet, P.; Burnier, M.; Campbell, H.; Chakravarti, A.; Chambers, J.C.; Chen, Y.I.; Collins, F.S.; Cooper, R.S.; Danesh, J.; Dedoussis, G.; de Faire, U.; Feranil, A.B.; Ferrières, J.; Ferrucci, L.; Freimer, N.B.; Gieger, C.; Groop, L.C.; Gudnason, V.; Gyllensten, U.; Hamsten, A.; Harris, T.B.; Hingorani, A.; Hirschhorn, J.N.; Hofman, A.; Hovingh, G.K.; Hsiung, C.A.; Humphries, S.E.; Hunt, S.C.; Hveem, K.; Iribarren, C.; Järvelin, M.; Jula, A.; Kähönen, M.; Kaprio, J.; Kesäniemi, A.; Kivimaki, M.; Kooner, J.S.; Koudstaal, P.J.; Krauss, R.M.; Kuh, D.; Kuusisto, J.; Kyvik, K.O.; Laakso, M.; Lakka, T.A.; Lind, L.; Lindgren, C.M.; Martin, N.G.; März, W.; Mccarthy, M.I.; Mckenzie, C.A.; Meneton, P.; Metspalu, A.; Moilanen, L.; Morris, A.D.; Munroe, P.B.; Njølstad, I.; Pedersen, N.L.; Power, C.; Pramstaller, P.P.; Price, J.F.; Psaty, B.M.; Quertermous, T.; Rauramaa, R.; Saleheen, D.; Salomaa, V.; Sanghera, D.K.; Saramies, J.; Schwarz, P.E.H.; Sheu, W.H.; Shuldiner, A.R.; Siegbahn, A.; Spector, T.D.; Stefansson, K.; Strachan, D.P.; Tayo, B.O.; Tremoli, E.; Tuomilehto, J.; Uusitupa, M.; van Duijn, C.M.; Vollenweider, P.; Wallentin, L.; Wareham, N.J.; Whitfield, J.B.; Wolffenbuttel, B.H.R.; Altshuler, D.; Ordovas, J.M.; Boerwinkle, E.; Palmer, C.N.A.; Thorsteinsdottir, U.; Chasman, D.I.; Rotter, J.I.; Franks, P.W.; Ripatti, S.; Cupples, L.A.; Sandhu, M.S.; Rich, S.S.; Boehnke, M.; Deloukas, P.; Mohlke, K.L.; Ingelsson, E.; Abecasis, G.R.; Daly, M.J.; Neale, B.M.; Kathiresan, S.

doi:10.1038/ng.2795

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10 -8 for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.

Common variants associated with plasma triglycerides and risk for coronary artery disease / R. Do, C.J. Willer, E.M. Schmidt, S. Sengupta, C. Gao, G.M. Peloso, S. Gustafsson, S. Kanoni, A. Ganna, J. Chen, M.L. Buchkovich, S. Mora, J.S. Beckmann, J.L. Bragg-Gresham, H. Chang, A. Demirkan, H.M. Den Hertog, L.A. Donnelly, G.B. Ehret, T. Esko, M.F. Feitosa, T. Ferreira, K. Fischer, P. Fontanillas, R.M. Fraser, D.F. Freitag, D. Gurdasani, K. Heikkilä, E. Hyppönen, A. Isaacs, A.U. Jackson, A. Johansson, T. Johnson, M. Kaakinen, J. Kettunen, M.E. Kleber, X. Li, J. Luan, L. Lyytikäinen, P.K.E. Magnusson, M. Mangino, E. Mihailov, M.E. Montasser, M. Müller-Nurasyid, I.M. Nolte, J.R. O'Connell, C.D. Palmer, M. Perola, A. Petersen, S. Sanna, R. Saxena, S.K. Service, S. Shah, D. Shungin, C. Sidore, C. Song, R.J. Strawbridge, I. Surakka, T. Tanaka, T.M. Teslovich, G. Thorleifsson, E.G. Van den Herik, B.F. Voight, K.A. Volcik, L.L. Waite, A. Wong, Y. Wu, W. Zhang, D. Absher, G. Asiki, I. Barroso, L.F. Been, J.L. Bolton, L.L. Bonnycastle, P. Brambilla, M.S. Burnett, G. Cesana, M. Dimitriou, A.S.F. Doney, A. Döring, P. Elliott, S.E. Epstein, G.I. Eyjolfsson, B. Gigante, M.O. Goodarzi, H. Grallert, M.L. Gravito, C.J. Groves, G. Hallmans, A. Hartikainen, C. Hayward, D. Hernandez, A.A. Hicks, H. Holm, Y. Hung, T. Illig, M.R. Jones, P. Kaleebu, J.J.P. Kastelein, K. Khaw, E. Kim, N. Klopp, P. Komulainen, M. Kumari, C. Langenberg, T. Lehtimäki, S. Lin, J. Lindström, R.J.F. Loos, F. Mach, W.L. McArdle, C. Meisinger, B.D. Mitchell, G. Müller, R. Nagaraja, N. Narisu, T.V.M. Nieminen, R.N. Nsubuga, I. Olafsson, K.K. Ong, A. Palotie, T. Papamarkou, C. Pomilla, A. Pouta, D.J. Rader, M.P. Reilly, P.M. Ridker, F. Rivadeneira, I. Rudan, A. Ruokonen, N. Samani, H. Scharnagl, J. Seeley, K. Silander, A. Stančáková, K. Stirrups, A.J. Swift, L. Tiret, A.G. Uitterlinden, L.J. van Pelt, S. Vedantam, N. Wainwright, C. Wijmenga, S.H. Wild, G. Willemsen, T. Wilsgaard, J.F. Wilson, E.H. Young, J.H. Zhao, L.S. Adair, D. Arveiler, T.L. Assimes, S. Bandinelli, F. Bennett, M. Bochud, B.O. Boehm, D.I. Boomsma, I.B. Borecki, S.R. Bornstein, P. Bovet, M. Burnier, H. Campbell, A. Chakravarti, J.C. Chambers, Y.I. Chen, F.S. Collins, R.S. Cooper, J. Danesh, G. Dedoussis, U. de Faire, A.B. Feranil, J. Ferrières, L. Ferrucci, N.B. Freimer, C. Gieger, L.C. Groop, V. Gudnason, U. Gyllensten, A. Hamsten, T.B. Harris, A. Hingorani, J.N. Hirschhorn, A. Hofman, G.K. Hovingh, C.A. Hsiung, S.E. Humphries, S.C. Hunt, K. Hveem, C. Iribarren, M. Järvelin, A. Jula, M. Kähönen, J. Kaprio, A. Kesäniemi, M. Kivimaki, J.S. Kooner, P.J. Koudstaal, R.M. Krauss, D. Kuh, J. Kuusisto, K.O. Kyvik, M. Laakso, T.A. Lakka, L. Lind, C.M. Lindgren, N.G. Martin, W. März, M.I. McCarthy, C.A. McKenzie, P. Meneton, A. Metspalu, L. Moilanen, A.D. Morris, P.B. Munroe, I. Njølstad, N.L. Pedersen, C. Power, P.P. Pramstaller, J.F. Price, B.M. Psaty, T. Quertermous, R. Rauramaa, D. Saleheen, V. Salomaa, D.K. Sanghera, J. Saramies, P.E.H. Schwarz, W.H. Sheu, A.R. Shuldiner, A. Siegbahn, T.D. Spector, K. Stefansson, D.P. Strachan, B.O. Tayo, E. Tremoli, J. Tuomilehto, M. Uusitupa, C.M. van Duijn, P. Vollenweider, L. Wallentin, N.J. Wareham, J.B. Whitfield, B.H.R. Wolffenbuttel, D. Altshuler, J.M. Ordovas, E. Boerwinkle, C.N.A. Palmer, U. Thorsteinsdottir, D.I. Chasman, J.I. Rotter, P.W. Franks, S. Ripatti, L.A. Cupples, M.S. Sandhu, S.S. Rich, M. Boehnke, P. Deloukas, K.L. Mohlke, E. Ingelsson, G.R. Abecasis, M.J. Daly, B.M. Neale, S. Kathiresan. - In: NATURE GENETICS. - ISSN 1061-4036. - 45:11(2013 Nov), pp. 1345-1352. [10.1038/ng.2795]

Common variants associated with plasma triglycerides and risk for coronary artery disease

R. Do;C. J. Willer;E. M. Schmidt;S. Sengupta;C. Gao;G. M. Peloso;S. Gustafsson;S. Kanoni;A. Ganna;J. Chen;M. L. Buchkovich;S. Mora;J. S. Beckmann;J. L. Bragg Gresham;H. Chang;A. Demirkan;H. M. Den Hertog;L. A. Donnelly;G. B. Ehret;T. Esko;M. F. Feitosa;T. Ferreira;K. Fischer;P. Fontanillas;R. M. Fraser;D. F. Freitag;D. Gurdasani;K. Heikkilä;E. Hyppönen;A. Isaacs;A. U. Jackson;A. Johansson;T. Johnson;M. Kaakinen;J. Kettunen;M. E. Kleber;X. Li;J. Luan;L. Lyytikäinen;P. K. E. Magnusson;M. Mangino;E. Mihailov;M. E. Montasser;M. Müller Nurasyid;I. M. Nolte;J. R. O'Connell;C. D. Palmer;M. Perola;A. Petersen;S. Sanna;R. Saxena;S. K. Service;S. Shah;D. Shungin;C. Sidore;C. Song;R. J. Strawbridge;I. Surakka;T. Tanaka;T. M. Teslovich;G. Thorleifsson;E. G. Van den Herik;B. F. Voight;K. A. Volcik;L. L. Waite;A. Wong;Y. Wu;W. Zhang;D. Absher;G. Asiki;I. Barroso;L. F. Been;J. L. Bolton;L. L. Bonnycastle;P. Brambilla;M. S. Burnett;G. Cesana;M. Dimitriou;A. S. F. Doney;A. Döring;P. Elliott;S. E. Epstein;G. I. Eyjolfsson;B. Gigante;M. O. Goodarzi;H. Grallert;M. L. Gravito;C. J. Groves;G. Hallmans;A. Hartikainen;C. Hayward;D. Hernandez;A. A. Hicks;H. Holm;Y. Hung;T. Illig;M. R. Jones;P. Kaleebu;J. J. P. Kastelein;K. Khaw;E. Kim;N. Klopp;P. Komulainen;M. Kumari;C. Langenberg;T. Lehtimäki;S. Lin;J. Lindström;R. J. F. Loos;F. Mach;W. L. McArdle;C. Meisinger;B. D. Mitchell;G. Müller;R. Nagaraja;N. Narisu;T. V. M. Nieminen;R. N. Nsubuga;I. Olafsson;K. K. Ong;A. Palotie;T. Papamarkou;C. Pomilla;A. Pouta;D. J. Rader;M. P. Reilly;P. M. Ridker;F. Rivadeneira;I. Rudan;A. Ruokonen;N. Samani;H. Scharnagl;J. Seeley;K. Silander;A. Stančáková;K. Stirrups;A. J. Swift;L. Tiret;A. G. Uitterlinden;L. J. van Pelt;S. Vedantam;N. Wainwright;C. Wijmenga;S. H. Wild;G. Willemsen;T. Wilsgaard;J. F. Wilson;E. H. Young;J. H. Zhao;L. S. Adair;D. Arveiler;T. L. Assimes;S. Bandinelli;F. Bennett;M. Bochud;B. O. Boehm;D. I. Boomsma;I. B. Borecki;S. R. Bornstein;P. Bovet;M. Burnier;H. Campbell;A. Chakravarti;J. C. Chambers;Y. I. Chen;F. S. Collins;R. S. Cooper;J. Danesh;G. Dedoussis;U. de Faire;A. B. Feranil;J. Ferrières;L. Ferrucci;N. B. Freimer;C. Gieger;L. C. Groop;V. Gudnason;U. Gyllensten;A. Hamsten;T. B. Harris;A. Hingorani;J. N. Hirschhorn;A. Hofman;G. K. Hovingh;C. A. Hsiung;S. E. Humphries;S. C. Hunt;K. Hveem;C. Iribarren;M. Järvelin;A. Jula;M. Kähönen;J. Kaprio;A. Kesäniemi;M. Kivimaki;J. S. Kooner;P. J. Koudstaal;R. M. Krauss;D. Kuh;J. Kuusisto;K. O. Kyvik;M. Laakso;T. A. Lakka;L. Lind;C. M. Lindgren;N. G. Martin;W. März;M. I. McCarthy;C. A. McKenzie;P. Meneton;A. Metspalu;L. Moilanen;A. D. Morris;P. B. Munroe;I. Njølstad;N. L. Pedersen;C. Power;P. P. Pramstaller;J. F. Price;B. M. Psaty;T. Quertermous;R. Rauramaa;D. Saleheen;V. Salomaa;D. K. Sanghera;J. Saramies;P. E. H. Schwarz;W. H. Sheu;A. R. Shuldiner;A. Siegbahn;T. D. Spector;K. Stefansson;D. P. Strachan;B. O. Tayo;E. Tremoli;J. Tuomilehto;M. Uusitupa;C. M. van Duijn;P. Vollenweider;L. Wallentin;N. J. Wareham;J. B. Whitfield;B. H. R. Wolffenbuttel;D. Altshuler;J. M. Ordovas;E. Boerwinkle;C. N. A. Palmer;U. Thorsteinsdottir;D. I. Chasman;J. I. Rotter;P. W. Franks;S. Ripatti;L. A. Cupples;M. S. Sandhu;S. S. Rich;M. Boehnke;P. Deloukas;K. L. Mohlke;E. Ingelsson;G. R. Abecasis;M. J. Daly;B. M. Neale;S. Kathiresan

2013

Abstract

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10 -8 for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.

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			Sì
		
	Lingua dell'articolo
	
			English
		
	Parole chiave
	
			Biological Transport ; Cholesterol, HDL ; Cholesterol, LDL ; Coronary Artery Disease ; Humans ; Polymorphism, Single Nucleotide ; Risk Factors ; Triglycerides
		
	Settori scientifico-disciplinari dell'articolo
	
			Settore BIO/14 - Farmacologia
		
	Tipo
	
			Articolo
		
	Revisione (peer review)
	
			Esperti anonimi
		
	Data di pubblicazione
	
			nov-2013
		
	Rivista in ANCE
	
			NATURE GENETICS
		
	Editore
	
			Nature Publishing Group
		
	Volume o annata
	
			45
		
	Fascicolo
	
			11
		
	Pagina iniziale
	
			1345
		
	Pagina finale
	
			1352
		
	Numero di pagine
	
			8
		
	Stato di pubblicazione
	
			Pubblicato
		
	Rilevanza del periodico
	
			Periodico con rilevanza internazionale
		
	DOI
	
			https://dx.doi.org/10.1038/ng.2795
		
	Identificativo ISI
	
			WOS:000326384100015
		
	Identificativo SCOPUS
	
			2-s2.0-84887058576
		
	Identificativo PUBMED
	
			24097064
		
	Tipologia
	
			info:eu-repo/semantics/article
		
	Citazione
	
			Common variants associated with plasma triglycerides and risk for coronary artery disease / R. Do, C.J. Willer, E.M. Schmidt, S. Sengupta, C. Gao, G.M. Peloso, S. Gustafsson, S. Kanoni, A. Ganna, J. Chen, M.L. Buchkovich, S. Mora, J.S. Beckmann, J.L. Bragg-Gresham, H. Chang, A. Demirkan, H.M. Den Hertog, L.A. Donnelly, G.B. Ehret, T. Esko, M.F. Feitosa, T. Ferreira, K. Fischer, P. Fontanillas, R.M. Fraser, D.F. Freitag, D. Gurdasani, K. Heikkilä, E. Hyppönen, A. Isaacs, A.U. Jackson, A. Johansson, T. Johnson, M. Kaakinen, J. Kettunen, M.E. Kleber, X. Li, J. Luan, L. Lyytikäinen, P.K.E. Magnusson, M. Mangino, E. Mihailov, M.E. Montasser, M. Müller-Nurasyid, I.M. Nolte, J.R. O'Connell, C.D. Palmer, M. Perola, A. Petersen, S. Sanna, R. Saxena, S.K. Service, S. Shah, D. Shungin, C. Sidore, C. Song, R.J. Strawbridge, I. Surakka, T. Tanaka, T.M. Teslovich, G. Thorleifsson, E.G. Van den Herik, B.F. Voight, K.A. Volcik, L.L. Waite, A. Wong, Y. Wu, W. Zhang, D. Absher, G. Asiki, I. Barroso, L.F. Been, J.L. Bolton, L.L. Bonnycastle, P. Brambilla, M.S. Burnett, G. Cesana, M. Dimitriou, A.S.F. Doney, A. Döring, P. Elliott, S.E. Epstein, G.I. Eyjolfsson, B. Gigante, M.O. Goodarzi, H. Grallert, M.L. Gravito, C.J. Groves, G. Hallmans, A. Hartikainen, C. Hayward, D. Hernandez, A.A. Hicks, H. Holm, Y. Hung, T. Illig, M.R. Jones, P. Kaleebu, J.J.P. Kastelein, K. Khaw, E. Kim, N. Klopp, P. Komulainen, M. Kumari, C. Langenberg, T. Lehtimäki, S. Lin, J. Lindström, R.J.F. Loos, F. Mach, W.L. McArdle, C. Meisinger, B.D. Mitchell, G. Müller, R. Nagaraja, N. Narisu, T.V.M. Nieminen, R.N. Nsubuga, I. Olafsson, K.K. Ong, A. Palotie, T. Papamarkou, C. Pomilla, A. Pouta, D.J. Rader, M.P. Reilly, P.M. Ridker, F. Rivadeneira, I. Rudan, A. Ruokonen, N. Samani, H. Scharnagl, J. Seeley, K. Silander, A. Stančáková, K. Stirrups, A.J. Swift, L. Tiret, A.G. Uitterlinden, L.J. van Pelt, S. Vedantam, N. Wainwright, C. Wijmenga, S.H. Wild, G. Willemsen, T. Wilsgaard, J.F. Wilson, E.H. Young, J.H. Zhao, L.S. Adair, D. Arveiler, T.L. Assimes, S. Bandinelli, F. Bennett, M. Bochud, B.O. Boehm, D.I. Boomsma, I.B. Borecki, S.R. Bornstein, P. Bovet, M. Burnier, H. Campbell, A. Chakravarti, J.C. Chambers, Y.I. Chen, F.S. Collins, R.S. Cooper, J. Danesh, G. Dedoussis, U. de Faire, A.B. Feranil, J. Ferrières, L. Ferrucci, N.B. Freimer, C. Gieger, L.C. Groop, V. Gudnason, U. Gyllensten, A. Hamsten, T.B. Harris, A. Hingorani, J.N. Hirschhorn, A. Hofman, G.K. Hovingh, C.A. Hsiung, S.E. Humphries, S.C. Hunt, K. Hveem, C. Iribarren, M. Järvelin, A. Jula, M. Kähönen, J. Kaprio, A. Kesäniemi, M. Kivimaki, J.S. Kooner, P.J. Koudstaal, R.M. Krauss, D. Kuh, J. Kuusisto, K.O. Kyvik, M. Laakso, T.A. Lakka, L. Lind, C.M. Lindgren, N.G. Martin, W. März, M.I. McCarthy, C.A. McKenzie, P. Meneton, A. Metspalu, L. Moilanen, A.D. Morris, P.B. Munroe, I. Njølstad, N.L. Pedersen, C. Power, P.P. Pramstaller, J.F. Price, B.M. Psaty, T. Quertermous, R. Rauramaa, D. Saleheen, V. Salomaa, D.K. Sanghera, J. Saramies, P.E.H. Schwarz, W.H. Sheu, A.R. Shuldiner, A. Siegbahn, T.D. Spector, K. Stefansson, D.P. Strachan, B.O. Tayo, E. Tremoli, J. Tuomilehto, M. Uusitupa, C.M. van Duijn, P. Vollenweider, L. Wallentin, N.J. Wareham, J.B. Whitfield, B.H.R. Wolffenbuttel, D. Altshuler, J.M. Ordovas, E. Boerwinkle, C.N.A. Palmer, U. Thorsteinsdottir, D.I. Chasman, J.I. Rotter, P.W. Franks, S. Ripatti, L.A. Cupples, M.S. Sandhu, S.S. Rich, M. Boehnke, P. Deloukas, K.L. Mohlke, E. Ingelsson, G.R. Abecasis, M.J. Daly, B.M. Neale, S. Kathiresan. - In: NATURE GENETICS. - ISSN 1061-4036. - 45:11(2013 Nov), pp. 1345-1352. [10.1038/ng.2795]
		
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			263
		
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			262
		
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			Periodico con Impact Factor
		
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			R. Do, C.J. Willer, E.M. Schmidt, S. Sengupta, C. Gao, G.M. Peloso, S. Gustafsson, S. Kanoni, A. Ganna, J. Chen, M.L. Buchkovich, S. Mora, J.S. Beckmann, J.L. Bragg Gresham, H. Chang, A. Demirkan, H.M. Den Hertog, L.A. Donnelly, G.B. Ehret, T. Esko, M.F. Feitosa, T. Ferreira, K. Fischer, P. Fontanillas, R.M. Fraser, D.F. Freitag, D. Gurdasani, K. Heikkilä, E. Hyppönen, A. Isaacs, A.U. Jackson, A. Johansson, T. Johnson, M. Kaakinen, J. Kettunen, M.E. Kleber, X. Li, J. Luan, L. Lyytikäinen, P.K.E. Magnusson, M. Mangino, E. Mihailov, M.E. Montasser, M. Müller Nurasyid, I.M. Nolte, J.R. O'Connell, C.D. Palmer, M. Perola, A. Petersen, S. Sanna, R. Saxena, S.K. Service, S. Shah, D. Shungin, C. Sidore, C. Song, R.J. Strawbridge, I. Surakka, T. Tanaka, T.M. Teslovich, G. Thorleifsson, E.G. Van den Herik, B.F. Voight, K.A. Volcik, L.L. Waite, A. Wong, Y. Wu, W. Zhang, D. Absher, G. Asiki, I. Barroso, L.F. Been, J.L. Bolton, L.L. Bonnycastle, P. Brambilla, M.S. Burnett, G. Cesana, M. Dimitriou, A.S.F. Doney, A. Döring, P. Elliott, S.E. Epstein, G.I. Eyjolfsson, B. Gigante, M.O. Goodarzi, H. Grallert, M.L. Gravito, C.J. Groves, G. Hallmans, A. Hartikainen, C. Hayward, D. Hernandez, A.A. Hicks, H. Holm, Y. Hung, T. Illig, M.R. Jones, P. Kaleebu, J.J.P. Kastelein, K. Khaw, E. Kim, N. Klopp, P. Komulainen, M. Kumari, C. Langenberg, T. Lehtimäki, S. Lin, J. Lindström, R.J.F. Loos, F. Mach, W.L. Mcardle, C. Meisinger, B.D. Mitchell, G. Müller, R. Nagaraja, N. Narisu, T.V.M. Nieminen, R.N. Nsubuga, I. Olafsson, K.K. Ong, A. Palotie, T. Papamarkou, C. Pomilla, A. Pouta, D.J. Rader, M.P. Reilly, P.M. Ridker, F. Rivadeneira, I. Rudan, A. Ruokonen, N. Samani, H. Scharnagl, J. Seeley, K. Silander, A. Stančáková, K. Stirrups, A.J. Swift, L. Tiret, A.G. Uitterlinden, L.J. van Pelt, S. Vedantam, N. Wainwright, C. Wijmenga, S.H. Wild, G. Willemsen, T. Wilsgaard, J.F. Wilson, E.H. Young, J.H. Zhao, L.S. Adair, D. Arveiler, T.L. Assimes, S. Bandinelli, F. Bennett, M. Bochud, B.O. Boehm, D.I. Boomsma, I.B. Borecki, S.R. Bornstein, P. Bovet, M. Burnier, H. Campbell, A. Chakravarti, J.C. Chambers, Y.I. Chen, F.S. Collins, R.S. Cooper, J. Danesh, G. Dedoussis, U. de Faire, A.B. Feranil, J. Ferrières, L. Ferrucci, N.B. Freimer, C. Gieger, L.C. Groop, V. Gudnason, U. Gyllensten, A. Hamsten, T.B. Harris, A. Hingorani, J.N. Hirschhorn, A. Hofman, G.K. Hovingh, C.A. Hsiung, S.E. Humphries, S.C. Hunt, K. Hveem, C. Iribarren, M. Järvelin, A. Jula, M. Kähönen, J. Kaprio, A. Kesäniemi, M. Kivimaki, J.S. Kooner, P.J. Koudstaal, R.M. Krauss, D. Kuh, J. Kuusisto, K.O. Kyvik, M. Laakso, T.A. Lakka, L. Lind, C.M. Lindgren, N.G. Martin, W. März, M.I. Mccarthy, C.A. Mckenzie, P. Meneton, A. Metspalu, L. Moilanen, A.D. Morris, P.B. Munroe, I. Njølstad, N.L. Pedersen, C. Power, P.P. Pramstaller, J.F. Price, B.M. Psaty, T. Quertermous, R. Rauramaa, D. Saleheen, V. Salomaa, D.K. Sanghera, J. Saramies, P.E.H. Schwarz, W.H. Sheu, A.R. Shuldiner, A. Siegbahn, T.D. Spector, K. Stefansson, D.P. Strachan, B.O. Tayo, E. Tremoli, J. Tuomilehto, M. Uusitupa, C.M. van Duijn, P. Vollenweider, L. Wallentin, N.J. Wareham, J.B. Whitfield, B.H.R. Wolffenbuttel, D. Altshuler, J.M. Ordovas, E. Boerwinkle, C.N.A. Palmer, U. Thorsteinsdottir, D.I. Chasman, J.I. Rotter, P.W. Franks, S. Ripatti, L.A. Cupples, M.S. Sandhu, S.S. Rich, M. Boehnke, P. Deloukas, K.L. Mohlke, E. Ingelsson, G.R. Abecasis, M.J. Daly, B.M. Neale, S. Kathiresan
		
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