Background:Hepatocellular carcinoma (HCC) has been associated to diabetes and obesity, but a possible association with the metabolic syndrome (MetS) and its potential interaction with hepatitis is open to discussion.Methods:We analysed data from an Italian case-control study, including 185 HCC cases and 404 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed from unconditional logistic regression models.Results:Among the MetS components, diabetes and obesity (i.e, body mass index (BMI)≥30 kg m-2) were positively associated to HCC risk, with ORs of 4.33 (95% CI, 1.89-9.86) and 1.97 (95% CI, 1.03-3.79), respectively. The ORs for the MetS were 4.06 (95% CI, 1.33-12.38) defining obesity as BMI≥25, and 1.92 (95% CI, 0.38-9.76) defining it as BMI≥30. The risk increased with the number of MetS components, up to an almost four-fold excess risk among subjects with ≥2 MetS factors. Among subjects without chronic infection with hepatitis B and/or C, the OR for those with ≥2 MetS components was over six-fold elevated. There was no consistent association in subjects with serological evidence of hepatitis B and/or C infection.Conclusion:This study found that the risk of HCC increases with the number of MetS components in subjects not chronically infected with hepatitis viruses.
Metabolic syndrome and hepatocellular carcinoma risk / F. Turati, R. Talamini, C. Pelucchi, J. Polesel, S. Franceschi, A. Crispo, F. Izzo, C. La Vecchia, P. Boffetta, M. Montella. - In: BRITISH JOURNAL OF CANCER. - ISSN 0007-0920. - 108:1(2013 Jan 15), pp. 222-228.
|Titolo:||Metabolic syndrome and hepatocellular carcinoma risk|
TURATI, FEDERICA (Primo)
|Parole Chiave:||Aged ; Carcinoma, Hepatocellular ; Case-Control Studies ; Diabetes Mellitus ; Female ; Hepatitis ; Humans ; Italy ; Liver Neoplasms ; Male ; Metabolic Syndrome X ; Middle Aged ; Obesity|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||15-gen-2013|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/bjc.2012.492|
|Appare nelle tipologie:||01 - Articolo su periodico|