The aim of this preliminary study was to explore the effect size of different dietary long chain polyunsaturated supplementations on blood lipid profile in children with primary hyperlipidemia. Thirty-six children (8-13 years) were recruited. After an 8-week stabilization period on the Step I diet, they were randomized to additionally receive for a 16-week period one capsule (500 mg) daily of docosahexaenoic acid (DHA) alone or a DHA plus eicosapentaenoic acid (EPA) mixture (45.6% DHA; 41.6% EPA) or wheat germ oil (control). An effect size (as percentage change from baseline) of +8%, -12% and -16% for high-density lipoprotein cholesterol (HDL-C), total cholesterol/HDL-C ratio and triglycerides was observed in children supplemented with DHA, compared to +2%, -8% and -12%, respectively, in children supplemented with DHA plus EPA. This preliminary study suggests powered trials appear feasible and are warranted to evaluate efficacy of n-3 long-chain polyunsaturated fatty acid dietary supplementations on the blood lipid profile of children with primary hyperlipidemia.
Blood lipids profile in hyperlipidemic children undergoing different dietary long chain polyunsaturated supplementations : a preliminary clinical trial / E. Verduci, C. Agostoni, G. Radaelli, G. Banderali, E. Riva, M. Giovannini. - In: INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION. - ISSN 0963-7486. - 65:3(2014 May), pp. 375-379.
|Titolo:||Blood lipids profile in hyperlipidemic children undergoing different dietary long chain polyunsaturated supplementations : a preliminary clinical trial|
VERDUCI, ELVIRA (Primo)
AGOSTONI, CARLO VIRGINIO (Secondo)
RIVA, ENRICA LICIA (Penultimo)
GIOVANNINI, MARCELLO (Ultimo)
|Parole Chiave:||DHA; EPA; Hyperlipidemia; LCPUFA|
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
|Data di pubblicazione:||mag-2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3109/09637486.2013.858239|
|Appare nelle tipologie:||01 - Articolo su periodico|