Evidence indicates that oxidative stress generation may contribute to health effects associated with particulate matter (PM) exposure. We investigated oxidative stress markers in 113 workers exposed to metal-rich PM and 61 non-exposed comparable volunteers. The plasma levels of soluble NOX2-derived peptide (sNOX2-dp) and two oxidative stress markers, urinary 8-hydroxydeoxyguanosine (8OH-dG) and 8-iso-prostaglandinF2alpha (8-iso-PGF2), were analysed. The plasma levels of the antioxidant alpha-tocopherol were also evaluated. The workers' average exposure to PM with aerodynamic diameter <10 μm (PM10) was much higher at the workplace than in the city where the volunteers lived. Workers had significantly higher urinary 8-iso-PGF2 and 8-OHdG and plasma sNOX2-dp levels than non-exposed subjects. Alpha-tocopherol was much lower in workers compared to non-exposed subjects. In multivariable regression models adjusted for age, body mass index and smoking, 8-iso-PGF2α increased in workers in association with PM10 and metal exposure; 8-OHdG and sNOX2-dp were associated only with iron. Alpha-tocopherol was inversely associated with each of the oxidative stress markers. Our observation leads to the hypothesis that the enhancement of oxidative stress markers associated with exposure to high metal-rich PM levels represents a possible step in the pathways leading from particle exposure to systemic (e.g., cardiovascular) effects.

Does enhancement of oxidative stress markers mediate health effects of ambient air particles? / P.A. Bertazzi, L. Cantone, P. Pignatelli, L. Angelici, V. Bollati, M. Bonzini, M. Carugno, P.M. Mannucci, F. Violi. - In: ANTIOXIDANTS & REDOX SIGNALING. - ISSN 1523-0864. - 21:1(2014 Jul 01), pp. 46-51. [10.1089/ars.2013.5694]

Does enhancement of oxidative stress markers mediate health effects of ambient air particles?

P.A. Bertazzi;L. Cantone;L. Angelici;V. Bollati;M. Bonzini;M. Carugno;P.M. Mannucci;
2014-07-01

Abstract

Evidence indicates that oxidative stress generation may contribute to health effects associated with particulate matter (PM) exposure. We investigated oxidative stress markers in 113 workers exposed to metal-rich PM and 61 non-exposed comparable volunteers. The plasma levels of soluble NOX2-derived peptide (sNOX2-dp) and two oxidative stress markers, urinary 8-hydroxydeoxyguanosine (8OH-dG) and 8-iso-prostaglandinF2alpha (8-iso-PGF2), were analysed. The plasma levels of the antioxidant alpha-tocopherol were also evaluated. The workers' average exposure to PM with aerodynamic diameter <10 μm (PM10) was much higher at the workplace than in the city where the volunteers lived. Workers had significantly higher urinary 8-iso-PGF2 and 8-OHdG and plasma sNOX2-dp levels than non-exposed subjects. Alpha-tocopherol was much lower in workers compared to non-exposed subjects. In multivariable regression models adjusted for age, body mass index and smoking, 8-iso-PGF2α increased in workers in association with PM10 and metal exposure; 8-OHdG and sNOX2-dp were associated only with iron. Alpha-tocopherol was inversely associated with each of the oxidative stress markers. Our observation leads to the hypothesis that the enhancement of oxidative stress markers associated with exposure to high metal-rich PM levels represents a possible step in the pathways leading from particle exposure to systemic (e.g., cardiovascular) effects.
pollution; workers
Settore MED/44 - Medicina del Lavoro
ANTIOXIDANTS & REDOX SIGNALING
Article (author)
File in questo prodotto:
File Dimensione Formato  
ars%2E2013%2E5694.pdf

non disponibili

Tipologia: Publisher's version/PDF
Dimensione 227.38 kB
Formato Adobe PDF
227.38 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/230143
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 15
  • ???jsp.display-item.citation.isi??? 12
social impact