Evidence indicates that oxidative stress generation may contribute to health effects associated with particulate matter (PM) exposure. We investigated oxidative stress markers in 113 workers exposed to metal-rich PM and 61 non-exposed comparable volunteers. The plasma levels of soluble NOX2-derived peptide (sNOX2-dp) and two oxidative stress markers, urinary 8-hydroxydeoxyguanosine (8OH-dG) and 8-iso-prostaglandinF2alpha (8-iso-PGF2), were analysed. The plasma levels of the antioxidant alpha-tocopherol were also evaluated. The workers' average exposure to PM with aerodynamic diameter <10 μm (PM10) was much higher at the workplace than in the city where the volunteers lived. Workers had significantly higher urinary 8-iso-PGF2 and 8-OHdG and plasma sNOX2-dp levels than non-exposed subjects. Alpha-tocopherol was much lower in workers compared to non-exposed subjects. In multivariable regression models adjusted for age, body mass index and smoking, 8-iso-PGF2α increased in workers in association with PM10 and metal exposure; 8-OHdG and sNOX2-dp were associated only with iron. Alpha-tocopherol was inversely associated with each of the oxidative stress markers. Our observation leads to the hypothesis that the enhancement of oxidative stress markers associated with exposure to high metal-rich PM levels represents a possible step in the pathways leading from particle exposure to systemic (e.g., cardiovascular) effects.
Does enhancement of oxidative stress markers mediate health effects of ambient air particles? / P.A. Bertazzi, L. Cantone, P. Pignatelli, L. Angelici, V. Bollati, M. Bonzini, M. Carugno, P.M. Mannucci, F. Violi. - In: ANTIOXIDANTS & REDOX SIGNALING. - ISSN 1523-0864. - 21:1(2014 Jul 01), pp. 46-51.
|Titolo:||Does enhancement of oxidative stress markers mediate health effects of ambient air particles?|
BERTAZZI, PIETRO ALBERTO (Primo)
CANTONE, LAURA (Secondo)
MANNUCCI, PIER MANNUCCIO (Penultimo)
|Parole Chiave:||pollution; workers|
|Settore Scientifico Disciplinare:||Settore MED/44 - Medicina del Lavoro|
|Data di pubblicazione:||1-lug-2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1089/ars.2013.5694|
|Appare nelle tipologie:||01 - Articolo su periodico|