INTRODUCTION: Effects of postresuscitation treatment with argon on neurologic recovery were investigated in a porcine model of cardiac arrest (CA) with an underlying acute myocardial infarction. METHODS: The left anterior descending coronary artery was occluded in 12 pigs, and CA was induced. After 8 min of untreated CA, cardiopulmonary resuscitation was performed for 5 min before defibrillation. Following resuscitation, animals were subjected to 4-h ventilation with 70% argon/30% oxygen or 70% nitrogen/30% oxygen. Myocardial function was echocardiographically assessed, and serum neuron-specific enolase was measured. Animals were observed up to 72 h for assessment of survival and neurologic recovery. RESULTS: All the animals were resuscitated and survived for 72 h, except for a control pig. Ventilation with argon did not have any detrimental effects on hemodynamics and respiratory gas exchange. All the six argon-treated animals had a fast and complete 72-h neurologic recovery, in contrast to only two of the six controls (P < 0.05). Seventy-two-hour neurologic alertness score and neurologic deficit score were, respectively, 100 and 0 in the argon group and 79 and 29 in the control one (P < 0.01 and P < 0.05). Significantly lower increases in serum neuron-specific enolase (12% vs. 234%) and minimal histological brain injury (neuronal degeneration: 0 vs. 1) were also observed in argon-treated animals, in comparison to controls. CONCLUSIONS: In this model, postresuscitation treatment with argon allowed for a faster and complete neurologic recovery, without detrimental effects on hemodynamics and respiratory gas exchanges.
Postresuscitation Treatment With Argon Improves Early Neurological Recovery in a Porcine Model of Cardiac Arrest / G. Ristagno, F. Fumagalli, I. Russo, S. Tantillo, D.D. Zani, V. Locatelli, M. De Maglie, D. Novelli, L. Staszewsky, T. Vago, A. Belloli, M. Di Giancamillo, M. Fries, S. Masson, E. Scanziani, R. Latini. - In: SHOCK. - ISSN 1073-2322. - 41:1(2014 Jan), pp. 72-78.
|Titolo:||Postresuscitation Treatment With Argon Improves Early Neurological Recovery in a Porcine Model of Cardiac Arrest|
FUMAGALLI, FRANCESCA (Secondo)
SCANZIANI, EUGENIO (Penultimo)
|Parole Chiave:||argon ; cardiac arrest ; neurologic outcome ; outcome ; post resuscitation|
|Settore Scientifico Disciplinare:||Settore VET/08 - Clinica Medica Veterinaria|
Settore VET/09 - Clinica Chirurgica Veterinaria
Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria
|Data di pubblicazione:||gen-2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1097/SHK.0000000000000049|
|Appare nelle tipologie:||01 - Articolo su periodico|
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