Lenalidomide is effective against relapsed chronic lymphocytic leukemia (CLL). We report the first case of long-term molecular remission with continuous lenalidomide treatment in a young patient with CLL relapsed to multiple treatments. Minimal residual disease was assessed by nested polymerase chain reaction on bone marrow samples with patient-specific primers. A 20-yr-old patient with standard-risk CLL was treated with lenalidomide after multiple relapses and achieved a 4 yr long complete molecular response with minimal toxicities. Published biologic data support that lenalidomide induces an immune-mediated control of CLL, and our case suggests that long-term treatment with lenalidomide is effective at a molecular level in patients with relapsed CLL.
Long-term molecular remission with lenalidomide treatment of relapsed chronic lymphocytic leukemia / F. Spina, F. Rezzonico, L. Farina, P. Corradini. - In: EUROPEAN JOURNAL OF HAEMATOLOGY. - ISSN 0902-4441. - 90:4(2013 Apr), pp. 340-344.
Long-term molecular remission with lenalidomide treatment of relapsed chronic lymphocytic leukemia
F. SpinaPrimo
;F. RezzonicoSecondo
;L. FarinaPenultimo
;P. CorradiniUltimo
2013
Abstract
Lenalidomide is effective against relapsed chronic lymphocytic leukemia (CLL). We report the first case of long-term molecular remission with continuous lenalidomide treatment in a young patient with CLL relapsed to multiple treatments. Minimal residual disease was assessed by nested polymerase chain reaction on bone marrow samples with patient-specific primers. A 20-yr-old patient with standard-risk CLL was treated with lenalidomide after multiple relapses and achieved a 4 yr long complete molecular response with minimal toxicities. Published biologic data support that lenalidomide induces an immune-mediated control of CLL, and our case suggests that long-term treatment with lenalidomide is effective at a molecular level in patients with relapsed CLL.Pubblicazioni consigliate
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