Different classes of squalene conjugates have been prepared: the first one containing a disulfide bond that, in the presence of glutathione, is able to trigger the release of a drug unit, the second one containing a tripepidyl sequence selectively cleaved by plasmin and also able to release a drug unit, the last one containinf a fluorescein 5(6)isothiocyanate unit. These compounds are able to self-assemble in water and can improve the delivery of active drugs to tumor tissues and can be helpful in the understanding of nanoparticle cellular uptake.
CHEMICAL APPROACHES FOR IMPROVING DRUG DELIVERY OF KNOWN ANTICANCER COMPOUNDS / S. Borrelli ; tutor: D. Passarella ; coordinator: E. Licandro. DIPARTIMENTO DI CHIMICA, 2014 Jan 14. 26. ciclo, Anno Accademico 2013. [10.13130/borrelli-stella_phd2014-01-14].
CHEMICAL APPROACHES FOR IMPROVING DRUG DELIVERY OF KNOWN ANTICANCER COMPOUNDS
S. Borrelli
2014
Abstract
Different classes of squalene conjugates have been prepared: the first one containing a disulfide bond that, in the presence of glutathione, is able to trigger the release of a drug unit, the second one containing a tripepidyl sequence selectively cleaved by plasmin and also able to release a drug unit, the last one containinf a fluorescein 5(6)isothiocyanate unit. These compounds are able to self-assemble in water and can improve the delivery of active drugs to tumor tissues and can be helpful in the understanding of nanoparticle cellular uptake.
| File | Dimensione | Formato | |
|---|---|---|---|
|
phd_unimi_R09025.pdf
accesso aperto
Tipologia:
Tesi di dottorato completa
Dimensione
4.45 MB
Formato
Adobe PDF
|
4.45 MB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
