Purpose. Clear cell (CC) and papillary serous carcinoma (PS) are histotypes at high risk of recurrence. We analyse patients’ survival in a retrospective series of 128 CC and PS endometrial cancer cases. Methods. All women with a histologically confirmed CC and PS endometrial cancer who underwent primary surgery in five institutions in Lombardy, Italy, were eligible for this study. A total of 77 (60.2 %) were PS endometrial cancer cases, 45 (35.2 %) CC cases and 6 (4.6 %) cases had mixed CC and PS histotype. Results. 54 (42 %) cases were diagnosed at stage I, 10 (8 %) at stage II, 47 (37 %) at stage III and 17 (13 %) at stage IV. Recurrence was observed in 49 cases (38.3 %). The median time at recurrence was 12 months (interquartile range 7–18). The rate of recurrence was 20.3 % in cases at stage I–lI and 56.2 % in cases at stage III–IV (p < 0.0001). With regard to the site of recurrence 24 recurrences were in and 52 outside the pelvis. Finally, the rate of recurrence was 32.6 % (14 cases) in CC cases, 43.1 % (31 cases) in PS cases and 66.7 % (4 cases) in cases with mixed histotype. The 5-year progression-free survival was 59.5 % (67.4 % for CC cases, 55.1 % for PS and mixed cases). Conclusion. In this study including CC and PS endometrial cancers, the 5-year survival from surgery was 72.7 % and the 5-year progression-free survival was 59.5 %.
Clear cell and papillary serous endometrial carcinomas : survival in a series of 128 cases / G. Scarfone, R. Secomandi, F. Parazzini, R. Viganò, G. Mangili, L. Frigerio, A. Villa, S. Tateo, E. Ricci, G. Bolis. - In: ARCHIVES OF GYNECOLOGY AND OBSTETRICS. - ISSN 0932-0067. - 287:2(2013 Feb), pp. 351-356.
|Titolo:||Clear cell and papillary serous endometrial carcinomas : survival in a series of 128 cases|
SCARFONE, GIOVANNA (Primo)
SECOMANDI, RITA (Secondo)
RICCI, ELENA DELFINA (Penultimo)
BOLIS, GIORGIO (Ultimo)
|Parole Chiave:||Endometrial cancer; Histotype; Survival|
|Settore Scientifico Disciplinare:||Settore MED/40 - Ginecologia e Ostetricia|
|Data di pubblicazione:||feb-2013|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s00404-012-2586-x|
|Appare nelle tipologie:||01 - Articolo su periodico|