In this brief article, the use of X-ray computed microtomography (CMT) for the visualization of the three-dimensional structure of pharmaceutical material is discussed. CMT is a non-destructive technique, which provides cross-sectional images based on local X-ray attenuation. The X-ray attenuation is then related to the material density. The results are discussed specifically with reference to the dissolution profile of a modified release tablet (Adalat OROS) at specific time points. This novel technique is complementary to standard compendial pharmaceutical tests, since it integrates information from several experimental methods to provide a more complete picture of specific drug-delivery systems.
|Titolo:||X-Ray Computed Microtomography for the Study of Modified Release Systems|
LORETI, GIULIA (Secondo)
|Parole Chiave:||X-ray computed microtomography ; modified release tablet ; Adalat OROS ; United States Pharmacopoeia dissolution apparatus II|
|Settore Scientifico Disciplinare:||Settore CHIM/09 - Farmaceutico Tecnologico Applicativo|
|Data di pubblicazione:||gen-2008|
|Appare nelle tipologie:||01 - Articolo su periodico|