Background. Multiple chemical sensitivity (MCS) is a chronic condition characterized by an exaggerated response to toxicants. We ascertained the prevalence of allergy to metals and toxicological aspects in MCS patients. Methods. We conducted a retrospective review of medical records of 41 patients with MCS. We performed patch testing (n = 21) for dental series and did lymphocyte transformation test (n = 18) for metals. We measured mercury in samples of blood (n = 19), urine (n = 19), saliva (n = 20), and scalp hair (n = 17) to investigate the association between mercury levels and cases of MCS. Results. The prevalence of metal immune hypersensitivity in a subset of 26 patients was 92.3 percent. Elevations of mercury occurred in 81.2 percent (26 of 32). The mean (±SD) in blood concentrations of mercury was 7.6 ± 13.6  μ g/L; mean in urine was 1.9 ± 2.5  μ g/L; mean in scalp hair was 2.2 ± 2.5  μ g/g; mean in saliva was 38.1 ± 52.1  μ g/L. Subgroup analyses showed that elevation of mercury levels in biological matrices were associated with mercury amalgams in patients with MCS (22 patients), compared with controls (8 patients) (odds ratio 11 : 95 percent confidence interval 1.5 to 81.6; P = 0.023). Conclusions. Our data show an increased prevalence of metal allergy and elevation of mercury levels in bioindicators among patients with MCS

Allergological and toxicological aspects in a multiple chemical sensitivity cohort / P. Pigatto, C. Minoia, A. Ronchi, L. Brambilla, S.M. Ferrucci, F. Spadari, M. Passoni, F. Somalvico, G. Bombeccari, G. Guzzi. - In: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. - ISSN 1942-0900. - 2013(2013 Nov), pp. 356235.1-356235.12. [10.1155/2013/356235]

Allergological and toxicological aspects in a multiple chemical sensitivity cohort

P. Pigatto
Primo
;
F. Spadari;G. Bombeccari;
2013-11

Abstract

Background. Multiple chemical sensitivity (MCS) is a chronic condition characterized by an exaggerated response to toxicants. We ascertained the prevalence of allergy to metals and toxicological aspects in MCS patients. Methods. We conducted a retrospective review of medical records of 41 patients with MCS. We performed patch testing (n = 21) for dental series and did lymphocyte transformation test (n = 18) for metals. We measured mercury in samples of blood (n = 19), urine (n = 19), saliva (n = 20), and scalp hair (n = 17) to investigate the association between mercury levels and cases of MCS. Results. The prevalence of metal immune hypersensitivity in a subset of 26 patients was 92.3 percent. Elevations of mercury occurred in 81.2 percent (26 of 32). The mean (±SD) in blood concentrations of mercury was 7.6 ± 13.6  μ g/L; mean in urine was 1.9 ± 2.5  μ g/L; mean in scalp hair was 2.2 ± 2.5  μ g/g; mean in saliva was 38.1 ± 52.1  μ g/L. Subgroup analyses showed that elevation of mercury levels in biological matrices were associated with mercury amalgams in patients with MCS (22 patients), compared with controls (8 patients) (odds ratio 11 : 95 percent confidence interval 1.5 to 81.6; P = 0.023). Conclusions. Our data show an increased prevalence of metal allergy and elevation of mercury levels in bioindicators among patients with MCS
Settore MED/35 - Malattie Cutanee e Veneree
Settore MED/28 - Malattie Odontostomatologiche
Settore MED/25 - Psichiatria
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/229065
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