We isolated a hybridoma cell line which produced monoclonal antibody to one determinant of an exoantigen of Candida albicans. The immunoglobulin G antibody product was characterized by using a Western blot technique and was used for a serological analysis of numerous homologous and heterologous yeast isolates. Based on specific immunologic determinants, C. albicans strains were identified and clustered into five groups. The monoclonal antibodies were effective reagents for identifying and serotyping our C. albicans isolates; they have potential application in the epidemiology of yeast infections.
|Titolo:||Specific and common antigenic determinants of Candida albicans isolates detected by monoclonal antibody|
MORACE, GIULIA (Ultimo)
|Parole Chiave:||animals ; antibodies, monoclonal ; antigens, fungal ; candida albicans ; epitopes ; fungal proteins ; hybridomas ; immunoglobulin G ; mice ; mice, inbred BALB C ; serotyping ; species specificity|
|Settore Scientifico Disciplinare:||Settore MED/07 - Microbiologia e Microbiologia Clinica|
|Data di pubblicazione:||feb-1986|
|Appare nelle tipologie:||01 - Articolo su periodico|