A new prophylactic and therapeutic antimicrobial strategy based on a specific physiological target that is effectively used by killer yeasts in their natural ecological competition is theorized. The natural system exploited is the yeast killer phenomenon previously adopted as an epidemiological marker for intraspecific differentiation of opportunistic yeasts, hyphomycetes, and bacteria. Pathogenic microorganisms (Candida albicans) may be susceptible to the activity of yeast killer toxins due to the presence of specific cell wall receptors. On the basis of the idiotypic network, we report that antiidiotypic antibodies, produced against a monoclonal antibody bearing the receptor-like idiotype, are in vivo protecting animals immunized through idiotypic vaccination and in vitro mimicking the antimicrobial activity of yeast killer toxins, thus acting as antibiotics.

Interfaces of the yeast killer phenomenon / L. Polonelli, S. Conti, M. Gerloni, W. Magliani, C. Chezzi, G. Morace. - In: CRITICAL REVIEWS IN MICROBIOLOGY. - ISSN 1040-841X. - 18:1(1991), pp. 47-87.

Interfaces of the yeast killer phenomenon

G. Morace
Ultimo
1991

Abstract

A new prophylactic and therapeutic antimicrobial strategy based on a specific physiological target that is effectively used by killer yeasts in their natural ecological competition is theorized. The natural system exploited is the yeast killer phenomenon previously adopted as an epidemiological marker for intraspecific differentiation of opportunistic yeasts, hyphomycetes, and bacteria. Pathogenic microorganisms (Candida albicans) may be susceptible to the activity of yeast killer toxins due to the presence of specific cell wall receptors. On the basis of the idiotypic network, we report that antiidiotypic antibodies, produced against a monoclonal antibody bearing the receptor-like idiotype, are in vivo protecting animals immunized through idiotypic vaccination and in vitro mimicking the antimicrobial activity of yeast killer toxins, thus acting as antibiotics.
No
English
adsorption ; antibodies, anti-idiotypic ; fungal proteins ; killer factors, yeast ; mycotoxins ; yeasts
Settore MED/07 - Microbiologia e Microbiologia Clinica
Articolo
Esperti anonimi
1991
CRC Press
18
1
47
87
41
Pubblicato
Periodico con rilevanza internazionale
info:eu-repo/semantics/article
Interfaces of the yeast killer phenomenon / L. Polonelli, S. Conti, M. Gerloni, W. Magliani, C. Chezzi, G. Morace. - In: CRITICAL REVIEWS IN MICROBIOLOGY. - ISSN 1040-841X. - 18:1(1991), pp. 47-87.
none
Prodotti della ricerca::01 - Articolo su periodico
6
262
Article (author)
no
L. Polonelli, S. Conti, M. Gerloni, W. Magliani, C. Chezzi, G. Morace
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/228170
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