Hyperbilirubinemia often accompanies liver failure; therefore, artificial liver support devices are currently used as a bridge to more definitive treatments to eliminate water-soluble and albumin-bound toxins. We report 2 patients, of which, after liver transplantation, the first experienced early allograft dysfunction and the other hyperbilirubinemia linked to chronic rejection. After 3 cycles of coupled plasma filtration adsorption (CPFA), the bilirubin promptly decreased in both cases. CPFA is an extracorporeal therapy that uses plasma filtration associated with an adsorbent cartridge and hemofiltration to remove cytokines and inflammatory mediators associated with septic shock, severe sepsis, and multiple organ dysfunction syndrome. Each cycle of treatment lowered the bilirubin of our patients by ∼40%. CPFA deserves attention as a potential inexpensive short-lasting device to treat hyperbilirubinemia after liver surgery or transplantation. Moreover, the effects of CPFA should be further studied to address inflammatory mediators in chronic rejection after liver transplantation or other immunologic disorders.

Hyperbilirubinemia after liver transplantation: the role of coupled plasma filtration adsorption / U. Maggi, G. Nita, S. Gatti, B. Antonelli, R. Paolo, G. Como, P. Messa, G. Rossi. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - 45:7(2013 Sep), pp. 2715-2717. (Intervento presentato al 36. convegno Congresso Nazionale S.I.T.O. tenutosi a Torino nel 2012) [10.1016/j.transproceed.2013.07.019].

Hyperbilirubinemia after liver transplantation: the role of coupled plasma filtration adsorption

G. Nita;P. Messa;G. Rossi
Ultimo
2013

Abstract

Hyperbilirubinemia often accompanies liver failure; therefore, artificial liver support devices are currently used as a bridge to more definitive treatments to eliminate water-soluble and albumin-bound toxins. We report 2 patients, of which, after liver transplantation, the first experienced early allograft dysfunction and the other hyperbilirubinemia linked to chronic rejection. After 3 cycles of coupled plasma filtration adsorption (CPFA), the bilirubin promptly decreased in both cases. CPFA is an extracorporeal therapy that uses plasma filtration associated with an adsorbent cartridge and hemofiltration to remove cytokines and inflammatory mediators associated with septic shock, severe sepsis, and multiple organ dysfunction syndrome. Each cycle of treatment lowered the bilirubin of our patients by ∼40%. CPFA deserves attention as a potential inexpensive short-lasting device to treat hyperbilirubinemia after liver surgery or transplantation. Moreover, the effects of CPFA should be further studied to address inflammatory mediators in chronic rejection after liver transplantation or other immunologic disorders.
Settore MED/18 - Chirurgia Generale
set-2013
Article (author)
File in questo prodotto:
File Dimensione Formato  
11-Hyperbilirubinemia After Liver Transplantation- The Role of Coupled plasma filtration adsorption.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 148.38 kB
Formato Adobe PDF
148.38 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/227736
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 11
social impact