IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca
IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.
AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishBackground and Aim: Chemoresistance often leads to loss of the last treatment option for cancer. 2-Methoxyestradiol (2-ME2) has been shown to inhibit tumor growth. The aim was to examine the efficacy of 2-ME2 on multidrug-resistant human cells from pancreatic and gastric cancer. Methods: We investigated the impact of 2-ME2 on multidrug-resistant cells derived from human pancreatic and gastric cancer cells that were positive or negative for the MDR1-gene. Results: In pancreatic cancer cells, growth inhibition was 57% in parental, 72% in MDR1-negative and 87% in MDR1-positive cells after 1 μmol/L 2-ME2. In gastric cancer cells we found a growth inhibition of 75% in parental, 82% in MDR1-positive and 95% in MDR1-negative cells. Strong induction of apoptosis was induced after a low dose of 2-ME2. No significant difference in the amount of apoptotic cells was observed between parental and multidrug-resistant cells of both tumor types. The number of apoptotic cells after 2-ME2 ranged from 7.5% in parental gastric cancer cells to 20.1% in MDR1-negative gastric cancer cells. Conclusion: 2-ME2 may therefore have clinical application for chemoresistant cancer.
Antineoplastic activity of 2-methoxyestradiol in human pancreatic and gastric cancer cells with different multidrug-resistant phenotypes / G. Schumacher, J. Hoffmann, T. Cramer, A. Spinelli, D. Jacob, M. Bahra, J. Pratschke, R. Pfitzmann, S. Schmidt, H. Lage. - In: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. - ISSN 0815-9319. - 22:9(2007 Sep), pp. 1469-1473.
| Titolo: | Antineoplastic activity of 2-methoxyestradiol in human pancreatic and gastric cancer cells with different multidrug-resistant phenotypes |
| Autori: | |
| Parole Chiave: | 2-methoxyestradiol; Gastric cancer; Multidrug resistance; Pancreatic cancer |
| Settore Scientifico Disciplinare: | Settore MED/18 - Chirurgia Generale |
| Data di pubblicazione: | set-2007 |
| Rivista: | |
| Tipologia: | Article (author) |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/j.1440-1746.2007.05033.x |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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