Hepatitis B virus infection is a global health problem. Based on the sequence divergence of the entire genome, hepatitis B virus has been classified into eight genotypes which have a characteristic geographic distribution. To date, no data are available on the molecular epidemiology of hepatitis B virus in Bulgaria. The aim of the present study was to reconstruct the epidemiological history of HBV genotypes/subgenotypes circulating in Bulgaria using a phylodynamic approach and a Bayesian statistical inference framework. Sequence analysis of the HBsAg/Reverse Transcriptase overlapping genomic regions revealed that D1 and A2 were the subgenotypes detected most frequently in the patients examined. The tMRCA estimations of the few HBV D1 Bulgarian significant clades dated back to 2327 years ago, corresponding to the early 1980s. The HBV A2 Bulgarian sequences fell into two closely related supported clusters dated to 2003 and 1996 years, respectively, suggesting a more recent introduction of subgenotype A2 into Bulgaria. The study provides new information about the HBV subgenotypes in Bulgaria.
Molecular analysis of hepatitis B virus in Bulgaria / M. Ciccozzi, M. Babakir-Mina, A. Lo Presti, R. Salpini, E. Cella, E. Gabanelli, P. Teoharov, A. Kevorkyan, C.F. Perno, G. Zehender, M. Ciotti. - In: JOURNAL OF MEDICAL VIROLOGY. - ISSN 0146-6615. - 85:1(2013 Jan), pp. 49-54.
|Titolo:||Molecular analysis of hepatitis B virus in Bulgaria|
ZEHENDER, GIANGUGLIELMO (Penultimo)
|Parole Chiave:||hepatitis B ; HBV subgenotypes ; Bayesian methods|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
Settore MED/42 - Igiene Generale e Applicata
Settore MED/07 - Microbiologia e Microbiologia Clinica
Settore MED/50 - Scienze Tecniche Mediche Applicate
|Data di pubblicazione:||gen-2013|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/jmv.23432|
|Appare nelle tipologie:||01 - Articolo su periodico|