Although dispensable, costimulation through CD28 facilitates activation of naive T lymphocytes. CD28 engagement led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements. Although not affecting TCR down- regulation, this process led to higher and more stable tyrosine phosphorylation of several substrates and higher consumption of Lck. These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains.

T lymphocyte costimulation mediated by reorganization of membrane microdomains / A. Viola, S. Schroeder, Y. Sakakibara, A. Lanzavecchia. - In: SCIENCE. - ISSN 0036-8075. - 283:5402(1999 Jan 29), pp. 680-682. [10.1126/science.283.5402.680]

T lymphocyte costimulation mediated by reorganization of membrane microdomains

A. Viola
Primo
;
1999

Abstract

Although dispensable, costimulation through CD28 facilitates activation of naive T lymphocytes. CD28 engagement led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements. Although not affecting TCR down- regulation, this process led to higher and more stable tyrosine phosphorylation of several substrates and higher consumption of Lck. These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains.
Lymphocyte Activation ; Antigen-Presenting Cells ; Antigens, CD28 ; Antigens, CD3 ; Cell Membrane ; G(M1) Ganglioside ; Humans ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck) ; Membrane Lipids ; Phosphorylation ; Phosphotyrosine ; Receptors, Antigen, T-Cell ; Signal Transduction ; T-Lymphocytes
Settore MED/04 - Patologia Generale
29-gen-1999
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/226747
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