Although dispensable, costimulation through CD28 facilitates activation of naive T lymphocytes. CD28 engagement led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements. Although not affecting TCR down- regulation, this process led to higher and more stable tyrosine phosphorylation of several substrates and higher consumption of Lck. These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains.
T lymphocyte costimulation mediated by reorganization of membrane microdomains / A. Viola, S. Schroeder, Y. Sakakibara, A. Lanzavecchia. - In: SCIENCE. - ISSN 0036-8075. - 283:5402(1999 Jan 29), pp. 680-682. [10.1126/science.283.5402.680]
T lymphocyte costimulation mediated by reorganization of membrane microdomains
A. ViolaPrimo
;
1999
Abstract
Although dispensable, costimulation through CD28 facilitates activation of naive T lymphocytes. CD28 engagement led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements. Although not affecting TCR down- regulation, this process led to higher and more stable tyrosine phosphorylation of several substrates and higher consumption of Lck. These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains.Pubblicazioni consigliate
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