It has been demonstrated that modified peptides which fail to induce detectable T cell responses can act as T cell receptor (TCR) antagonists when presented together with agonist by the same antigen-presenting cell (APC). We report that a TCR antagonist competitively inhibits TCR triggering induced by low-affinity ligands such as agonistic peptides or bacterial superantigens. However, the same antagonist cannot inhibit TCR triggering and T cell activation induced by high-affinity anti-CD3 antibodies that engage most TCR at once. These results indicate that TCR antagonists inhibit T cell responses by interfering with the ongoing process of serial triggering, rather than by delivering an inhibitory signal to T cells.
|Titolo:||A T cell receptor (TCR) antagonist competitively inhibits serial TCR triggering by low-affinity ligands, but does not affect triggering by high-affinity anti-CD3 antibodies|
VIOLA, ANTONELLA (Primo)
|Parole Chiave:||Bacterial Toxins; Superantigens; Antibodies, Monoclonal; Antigens, CD3; Binding, Competitive; Clone Cells; Down-Regulation; Enterotoxins; Humans; Ligands; Lymphocyte Activation; Peptide Fragments; Receptors, Antigen, T-Cell; T-Lymphocytes|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||nov-1997|
|Digital Object Identifier (DOI):||10.1002/eji.1830271146|
|Appare nelle tipologie:||01 - Articolo su periodico|