The effect of two different single oral doses of loxiglumide (CR 1505, CAS 107097-80-3) on gall-bladder emptying induced by a 550-cal standard mixed meal in 6 healthy volunteers was studied. Following placebo, the maximal gall-bladder emptying occurred about 90 min after the meal (minimal residual gall-bladder volume 27.4% of basal volume). Loxiglumide 400 or 800 mg dose-dependently inhibited the physiologica gall-bladder emptying. Loxiglumide plasma levels dose-dependently increased. The inhibition of gall-bladder emptying and the kinetic of loxiglumide plasma levels were temporally related. The results of the present study confirm that oral loxiglumide is a potent orally active cholecystokinin (CCK) antagonist in man and that CCK is the major physiological mediator of gallbladder emptying in response to meal

Dose-response effects of oral loxiglumide on postprandial gall-bladder emptying in man / A. Malesci, C. De Fazio, S. Festorazzi, C. Bonato, A. Valentini, M. Tacconi, M. Bekkering, G. Giacovelli, M. D'Amato, L.C. Rovati. - In: ARZNEIMITTEL-FORSCHUNG. - ISSN 0004-4172. - 42:11(1992 Nov), pp. 1359-1362.

Dose-response effects of oral loxiglumide on postprandial gall-bladder emptying in man

A. Malesci
Primo
;
1992-11

Abstract

The effect of two different single oral doses of loxiglumide (CR 1505, CAS 107097-80-3) on gall-bladder emptying induced by a 550-cal standard mixed meal in 6 healthy volunteers was studied. Following placebo, the maximal gall-bladder emptying occurred about 90 min after the meal (minimal residual gall-bladder volume 27.4% of basal volume). Loxiglumide 400 or 800 mg dose-dependently inhibited the physiologica gall-bladder emptying. Loxiglumide plasma levels dose-dependently increased. The inhibition of gall-bladder emptying and the kinetic of loxiglumide plasma levels were temporally related. The results of the present study confirm that oral loxiglumide is a potent orally active cholecystokinin (CCK) antagonist in man and that CCK is the major physiological mediator of gallbladder emptying in response to meal
Adult; Cholecystokinin; Dose-Response Relationship, Drug; Double-Blind Method; Food; Gallbladder; Gallbladder Emptying; Humans; Male; Proglumide
Settore MED/12 - Gastroenterologia
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/226560
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