Cholecystokinin-8 like immunoreactivity (CCK-8 IR) was measured in different brain regions of rats with experimental liver cirrhosis. A statistically significant reduction of CCK-8 content was observed in the hypothalamus of cirrhotic rats. No significant modification of brain CCK fractionation pattern was observed in treated animals as compared to controls. The decrease of CCK-8 IR parallels the recently reported hypothalamic depletion of beta endorphin in cirrhotic rats confirming that central neuropeptides are affected by chronic liver failure.

Brain cholecystokinin-8 immunoreactivity in rats with experimental liver cirrhosis / F. Salerno, C. Bonato, A.E. Panerai, A. Martini, A. Malesci. - In: LIFE SCIENCES. - ISSN 0024-3205. - 33:4(1983 Jul 25), pp. 377-381.

Brain cholecystokinin-8 immunoreactivity in rats with experimental liver cirrhosis

A.E. Panerai;A. Malesci
Ultimo
1983-07-25

Abstract

Cholecystokinin-8 like immunoreactivity (CCK-8 IR) was measured in different brain regions of rats with experimental liver cirrhosis. A statistically significant reduction of CCK-8 content was observed in the hypothalamus of cirrhotic rats. No significant modification of brain CCK fractionation pattern was observed in treated animals as compared to controls. The decrease of CCK-8 IR parallels the recently reported hypothalamic depletion of beta endorphin in cirrhotic rats confirming that central neuropeptides are affected by chronic liver failure.
Animals ; Brain ; Cerebral Cortex ; Cholecystokinin ; Hypothalamus ; Liver Cirrhosis, Experimental ; Male ; Peptide Fragments ; Rats ; Rats, Inbred Strains ; Sincalide
Settore MED/12 - Gastroenterologia
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/226547
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