Purpose: To study corneal copper deposits in Wilson's disease (WD) patients by traditional biomicroscopy and in vivo laser scanning confocal microscopy (LSCM). Methods: Twenty WD patients and 20 matched controls underwent an ophthalmic examination in one eye randomly chosen, including slit lamp biomicroscopy with Goldmann's three-mirror contact lens examination and LSCM, in order to evaluate copper deposits in the peripheral cornea. Results: No control subjects had corneal changes at both traditional biomicroscopy and LSCM. Only 25% of WD patients had detectable slit lamp changes, compared with 75% with LSCM examination. All cases detected by slit lamp were detected by LSCM. A significant correlation (p < 0.01) was found between deposit intensity at LSCM and daily urinary copper excretion. Conclusion: LSCM could detect copper deposition in WD corneas in more patients than traditional examination; it may therefore provide important information in cases of suspected WD diagnosis.
Study of corneal copper deposits in Wilson's disease by in vivo confocal microscopy / G. Ceresara, P. Fogagnolo, M. Zuin, S. Zatelli, J. Bovet, L. Rossetti. - In: OPHTHALMOLOGICA. - ISSN 0030-3755. - 231:3(2014), pp. 147-152.
|Titolo:||Study of corneal copper deposits in Wilson's disease by in vivo confocal microscopy|
FOGAGNOLO, PAOLO (Corresponding)
|Parole Chiave:||Corneal copper microdeposits; Corneal laser scanning confocal microscopy; Kayser-Fleischer ring; Wilson's disease; Adult; Ceruloplasmin; Copper; Corneal Diseases; Cross-Sectional Studies; Female; Hepatolenticular Degeneration; Humans; Male; Microscopy; Microscopy, Confocal|
|Settore Scientifico Disciplinare:||Settore MED/30 - Malattie Apparato Visivo|
Settore MED/12 - Gastroenterologia
|Data di pubblicazione:||2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1159/000355090|
|Appare nelle tipologie:||01 - Articolo su periodico|