We described a novel tumor-associated immunosuppressive mechanism based on post-translational modifications of chemokines by reactive nitrogen species (RNS). To overcome tumor immunosuppressive hindrances, we designed and developed a new drug, AT38, that inhibits RNS generation at the tumor site. Combinatorial approaches with AT38 boost the effectiveness of cancer immunotherapy protocols.
Smoothing T cell roads to the tumor: Chemokine post-translational regulation / B. Molon, A. Viola, V. Bronte. - In: ONCOIMMUNOLOGY. - ISSN 2162-4011. - 1:3(2012 May 01), pp. 390-392. [10.4161/onci.19069]
Smoothing T cell roads to the tumor: Chemokine post-translational regulation
A. ViolaSecondo
;
2012
Abstract
We described a novel tumor-associated immunosuppressive mechanism based on post-translational modifications of chemokines by reactive nitrogen species (RNS). To overcome tumor immunosuppressive hindrances, we designed and developed a new drug, AT38, that inhibits RNS generation at the tumor site. Combinatorial approaches with AT38 boost the effectiveness of cancer immunotherapy protocols.
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