The analgesic effect of acute or chronic nortriptyline, amitriptyline and their effects on morphine induced analgesia were evaluated in the rat. Clomipramine and amitriptyline, but not Nortriptyline, induce analgesia, while all potentiate the effect of morphine when administered acutely. The analgesic effect of clomipramine is blunted by both the serotonin antagonist metergoline and the opiate receptor blocker naloxone, thus indicating an involvement of both the serotoninergic and endogenous opioid system. The involvement of the serotoninergic system is confirmed by the similar results obtained with the serotonin precursor 5-hydroxytryptophan administered alone or together with morphine. A relation between the serotoninergic and the endogenous opioid systems is also shown by the increase in hypothalamic beta-endorphin concentrations elicited by all the drugs used after acute or chronic treatment, with the only exception of nortriptyline, that has been shown to exert its effects mainly through the noradrenergic system. In conclusion, the analgesic effect of clomipramine and amitriptyline and their potentiation of morphine induced analgesia seems to be related to an activation of the endogenous opioid system mediated by serotonin.
A role for serotonin and beta-endorphin in the analgesia induced by some tricyclic antidepressant drugs / P. Sacerdote, A. Brini, P. Mantegazza, A.E. Panerai. - In: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. - ISSN 0091-3057. - 26:1(1987 Jan), pp. 153-158.
|Titolo:||A role for serotonin and beta-endorphin in the analgesia induced by some tricyclic antidepressant drugs|
SACERDOTE, PAOLA GIUSEPPINA (Primo)
BRINI, ANNA TERESA (Secondo)
PANERAI, ALBERTO EMILIO (Ultimo)
|Parole Chiave:||Analgesia ; 5-Hydroxytryptophan ; Amitriptyline ; Animals ; Antidepressive Agents, Tricyclic ; Clomipramine ; Endorphins ; Nortriptyline ; Rats ; Rats, Inbred Strains ; Serotonin ; beta-Endorphin|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||gen-1987|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0091-3057(87)90548-X|
|Appare nelle tipologie:||01 - Articolo su periodico|