Capsaicin, a neurotoxic agent that induces a decrease in hypothalamic beta-endorphin, a specific antiserum and human beta-endorphin fragment 6 31, a peptidergic beta-endorphin antagonist have been used in the attempt of selectively affecting the function of beta-endorphinergic system and of evaluating the possible role of this peptide in the analgesic effect of morphine. All 3 experimental approaches resulted in a decrease of the analgesia induced by morphine, thus suggesting that beta-endorphin is involved in the effect of morphine.
Analgesic effect of morphine: a role for beta-endorphin / A.E. Panerai, P. Sacerdote, A. Brini, P. Mantegazza. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 74:3(1987 Mar 09), pp. 348-352.
Analgesic effect of morphine: a role for beta-endorphin
A.E. PaneraiPrimo
;P. SacerdoteSecondo
;A. BriniPenultimo
;
1987
Abstract
Capsaicin, a neurotoxic agent that induces a decrease in hypothalamic beta-endorphin, a specific antiserum and human beta-endorphin fragment 6 31, a peptidergic beta-endorphin antagonist have been used in the attempt of selectively affecting the function of beta-endorphinergic system and of evaluating the possible role of this peptide in the analgesic effect of morphine. All 3 experimental approaches resulted in a decrease of the analgesia induced by morphine, thus suggesting that beta-endorphin is involved in the effect of morphine.
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