The concentrations of brain and spinal cord beta-endorphin, met-enkephalin, dynorphin and substance P were measured in rats bearing the Freund adjuvant induced arthritis. Beta-endorphin brain concentrations decreased gradually in time with a nadir on day twenty-one, when arthritis was at its maximum, and were back to normal by day thirty-five, when arthritis was no more evident. Met-enkephalin concentrations increased in brain areas and in the lumbar spinal cord and returned to normal with the same time pattern, while dynorphin and substance P concentrations did not change. These data indicate that peripheral lesions can induce important changes in brain concentrations of some opioid peptides involved in the modulation of pain.
|Titolo:||Brain and spinal cord neuropeptides in adjuvant induced arthritis in rats|
|Parole Chiave:||Animals ; Arthritis ; Arthritis, Experimental ; Brain ; Dynorphins ; Endorphins ; Enkephalin, Methionine ; Male ; Neuropeptides ; Rats ; Rats, Inbred Strains ; Spinal Cord ; Substance P ; Time Factors ; Tissue Distribution ; beta-Endorphin|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||7-set-1987|
|Digital Object Identifier (DOI):||10.1016/0024-3205(87)90209-8|
|Appare nelle tipologie:||01 - Articolo su periodico|