In recent years, an increasing effort has been devoted to the optimization of acquisition and reconstruction schemes for fluorescence molecular tomography (FMT). In particular, wide-field structured illumination and compression of the measured images have enabled significant reduction of the data set and, consequently, a decrease in both acquisition and processing times. FMT based on this concept has been recently demonstrated on a cylindrical phantom with a rotating-view scheme that significantly increases the reconstruction quality. In this work, we generalize the rotating-view scheme to arbitrary geometries and experimentally demonstrate its applicability to murine models. To the best of our knowledge this is the first time that FMT based on a rotating-view scheme with structured illumination and image compression has been applied to animals.
Fluorescence molecular tomography of an animal model using structured light rotating view acquisition / N. Ducros, A. Bassi, G. Valentini, G. Canti, S. Arridge, C. D'Andrea. - In: JOURNAL OF BIOMEDICAL OPTICS. - ISSN 1083-3668. - 18:2(2013 Feb 18), pp. 020503.1-020503.4. [10.1117/1.JBO.18.2.020503]
Fluorescence molecular tomography of an animal model using structured light rotating view acquisition
G. Canti;
2013
Abstract
In recent years, an increasing effort has been devoted to the optimization of acquisition and reconstruction schemes for fluorescence molecular tomography (FMT). In particular, wide-field structured illumination and compression of the measured images have enabled significant reduction of the data set and, consequently, a decrease in both acquisition and processing times. FMT based on this concept has been recently demonstrated on a cylindrical phantom with a rotating-view scheme that significantly increases the reconstruction quality. In this work, we generalize the rotating-view scheme to arbitrary geometries and experimentally demonstrate its applicability to murine models. To the best of our knowledge this is the first time that FMT based on a rotating-view scheme with structured illumination and image compression has been applied to animals.Pubblicazioni consigliate
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