PURPOSE: To evaluate with contrast MR the evolution in size, signal, and contrast enhancement of optic pathway lesions in four patients with neurofibromatosis type 1. METHODS: The four reported patients are children with ages ranging from 21 months to 13 years affected by neurofibromatosis type 1 and optic pathway lesions. No treatment of the optic pathway lesions was carried out in these patients. They have been followed by serial contrast MR. RESULTS: In all patients a change in size, signal, and enhancement of optic pathways lesions was noted with time, and in the last follow-up study a marked reduction in size and enhancement of optic pathway lesions was observed in all cases. CONCLUSIONS: Modification and regression of optic pathway lesions with spontaneous disappearance of the enhancement is demonstrated. This finding could have a crucial influence on the therapeutic approach of the optic pathway lesions.

Spontaneous involution of optic pathway lesions in neurofibromatosis type 1 : serial contrast MR evaluation / C. Parazzini, F. Triulzi, E. Bianchini, V. Agnetti, M. Conti, C. Zanolini, M.M. Maninetti, L.N. Rossi, G. Scotti. - In: AJNR, AMERICAN JOURNAL OF NEURORADIOLOGY. - ISSN 0195-6108. - 16:8(1995 Sep), pp. 1711-1718.

Spontaneous involution of optic pathway lesions in neurofibromatosis type 1 : serial contrast MR evaluation

F. Triulzi;L.N. Rossi
Penultimo
;
1995

Abstract

PURPOSE: To evaluate with contrast MR the evolution in size, signal, and contrast enhancement of optic pathway lesions in four patients with neurofibromatosis type 1. METHODS: The four reported patients are children with ages ranging from 21 months to 13 years affected by neurofibromatosis type 1 and optic pathway lesions. No treatment of the optic pathway lesions was carried out in these patients. They have been followed by serial contrast MR. RESULTS: In all patients a change in size, signal, and enhancement of optic pathways lesions was noted with time, and in the last follow-up study a marked reduction in size and enhancement of optic pathway lesions was observed in all cases. CONCLUSIONS: Modification and regression of optic pathway lesions with spontaneous disappearance of the enhancement is demonstrated. This finding could have a crucial influence on the therapeutic approach of the optic pathway lesions.
Adolescent ; Child ; Child, Preschool ; Contrast Media ; Cranial Nerve Neoplasms ; Drug Combinations ; Female ; Follow-Up Studies ; Gadolinium DTPA ; Humans ; Infant ; Magnetic Resonance Imaging ; Male ; Meglumine ; Neurofibromatosis 1 ; Optic Nerve ; Optic Nerve Diseases ; Organometallic Compounds ; Pentetic Acid
Settore MED/38 - Pediatria Generale e Specialistica
Settore MED/39 - Neuropsichiatria Infantile
Settore MED/37 - Neuroradiologia
set-1995
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/225998
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