OBJECTIVES: Transcranial direct current stimulation (tDCS) is a non-invasive neurostimulation technique that has received increasing interest in the area of mood disorders over the last several years. While acute, double-blind, sham-controlled studies have already reported positive findings in terms of efficacy and safety for tDCS, follow-up data are lacking. This need prompted the present follow-up study, which assesses post-acute effects of tDCS (no maintenance stimulation was performed), in the mid-term, in a sample of major depressives. Methods After completing an acute, open trial of tDCS, 23 outpatients with either major depressive disorder or bipolar disorder entered a naturalistic follow-up (T1) with clinical evaluations at one week (T2), 1 month (T3), and 3 months (T4). A quantitative analysis of Hamilton Depression Rating Scale (HAM-D), Montgomery-Asberg Depression Rating Scale (MADRS), and Young Mania Rating Scale (YMRS) total scores, through repeated measures analysis of variance (ANOVA) (T1-T4) and paired t-test for comparing specific time points (T1-T2, T2-T3, and T3-T4), was performed. In addition, a qualitative analysis on the basis of treatment response and remission (HAM-D) was performed. RESULTS: Even though a progressive reduction of follow-up completers was observed from T2 to T4 (95.6% at T2, 65.2% at T3, and 47.8% at T4), the antidepressant effects of acute tDCS persisted over 3 months in almost half of the sample. Of note, no post-acute side effects emerged during the follow-up observation. The most frequent causes of drop-out from this study included major modifications in therapeutic regimen (30%) and poor adherence to follow-up visits (17%). CONCLUSIONS: In this mid-term, open, follow-up study, tDCS showed mixed results. Further controlled studies are urgently needed to assess its effects beyond the acute phase.
Augmentative transcranial direct current stimulation (tDCS) in poor responder depressed patients : a follow-up study / B. Dell'Osso, C. Dobrea, C. Arici, B. Benatti, R. Ferrucci, M. Vergari, A. Priori, A.C. Altamura. - In: CNS SPECTRUMS. - ISSN 1092-8529. - 19:4(2014 Aug), pp. 347-354.
|Titolo:||Augmentative transcranial direct current stimulation (tDCS) in poor responder depressed patients : a follow-up study|
DELL'OSSO, BERNARDO MARIA (Primo)
DOBREA, CRISTINA ROXANA MIHAELA (Secondo)
PRIORI, ALBERTO (Penultimo)
ALTAMURA, ALFREDO CARLO (Ultimo)
|Parole Chiave:||Bipolar disorder; follow-up observation; major depressive disorder; poor response; transcranial direct current stimulation (tDCS)|
|Settore Scientifico Disciplinare:||Settore MED/25 - Psichiatria|
Settore MED/26 - Neurologia
Settore M-PSI/01 - Psicologia Generale
|Data di pubblicazione:||ago-2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1017/S1092852913000497|
|Appare nelle tipologie:||01 - Articolo su periodico|