Background: Chronic cerebrospinal venous insufficiency (CCSVI) has been proposed as a possible cause of multiple sclerosis (MS). Objectives: The CoSMo study evaluated the association between CCSVI and MS. Methods: The primary end-point of this multicentric, case-control study was to compare the prevalence of CCSVI between patients with MS, patients with other neurodegenerative diseases (ONDs) and healthy controls (HCs). Color-coded duplex sonography was performed by a sonologist and the images were sent to one of three central sonologists for a second reading. Agreement between local and central sonologists or, in case of disagreement, the predominant judgment among the three central readers, was required for a diagnosis of CCSVI. All readings, data collection and analysis were blinded. Results: The study involved 35 MS centers across Italy and included 1874 subjects aged 18-55. 1767 (94%) were evaluable: 1165 MS patients, 226 patients with ONDs and 376 HCs. CCSVI prevalence was 3.26%, 3.10% and 2.13% for the MS, OND and HC groups, respectively. No significant difference in CCSVI prevalence was found amongst the three cohorts (MS versus HC, OR = 1.55, 95%CI = 0.72-3.36, ρ= 0.30; OND versus HC, OR = 1.47, 95%CI = 0.53-4.11, ρ= 0.46; MS versus OND, OR = 1.05, 95%CI = 0.47-2.39, ρ = 0.99). High negative and low positive agreement was found between the local and centralized readers. Conclusions: CCSVI is not associated with MS.
Observational case-control study of the prevalence of chronic cerebrospinal venous insufficiency in multiple sclerosis: results from the CoSMo study / G. Comi, M.A. Battaglia, A. Bertolotto, M. Del Sette, A. Ghezzi, G. Malferrari, M. Salvetti, M.P. Sormani, L. Tesio, E. Stolz, P. Zaratin, G. Mancardi. - In: MULTIPLE SCLEROSIS. - ISSN 1352-4585. - 19:11(2013), pp. 1508-1517.
|Titolo:||Observational case-control study of the prevalence of chronic cerebrospinal venous insufficiency in multiple sclerosis: results from the CoSMo study|
|Parole Chiave:||Chronic cerebrospinal venous insufficiency ; circulatory system ; Italy ; multicentric study ; multiple sclerosis ; neurodegenerative disease ; prevalence study ; sonography|
|Settore Scientifico Disciplinare:||Settore MED/34 - Medicina Fisica e Riabilitativa|
Settore MED/26 - Neurologia
|Data di pubblicazione:||2013|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1177/1352458513501231|
|Appare nelle tipologie:||01 - Articolo su periodico|