Exercise performed at a competitive level could deeply modify the immune system and the cytokine response of athletes. In this report, we demonstrated that young elite female artistic gymnasts (n = 16; age: 9-15 years) showed an increase of interleukin 6 (IL-6) and tumour necrosis factor alpha (TNF-α) mRNA expression in blood mononuclear cells (PBMCs), in comparison to girls performing the same sport at a recreational level (n = 16; age: 10-15 years). The increase of IL-6 and TNF-α mRNAs appeared to be directly linked to the intensity and duration of the training. Moreover, in elite athletes engaged in artistic gymnastics or in synchronised swimming (n =34; age: 9-15 years), IL-6 gene expression appeared to be modulated by the levels of circulating oestrogens: pre-pubertal athletes (n = 20; age: 11 ± 1 years) revealed a higher increase in IL-6 than pubertal athletes (n = 14; age: 14 ± 1.6 years). In pre-pubertal athletes, body mass index (BMI) percentile was inversely correlated with the increase of both IL-6 and TNF-α. The consequence of these events was the shift of the cytokine profile towards a pro-inflammatory status. These modifications, induced by training performed at an elite level, might negatively affect the growth of female children athletes.
Protective role of 17-β-estradiol towards IL-6 leukocyte expression induced by intense training in young female athletes / C. Tringali, L. Scala, I. Silvestri, J. Vitale, R. Scurati, G. Michielon, G. Alberti, B. Venerando. - In: JOURNAL OF SPORTS SCIENCES. - ISSN 0264-0414. - 32:5(2014), pp. 452-461.
|Titolo:||Protective role of 17-β-estradiol towards IL-6 leukocyte expression induced by intense training in young female athletes|
TRINGALI, CRISTINA ALESSANDRA (Primo)
ALBERTI, GIAMPIETRO (Penultimo)
VENERANDO, BRUNO (Ultimo)
|Parole Chiave:||17-β-estradiol; children athletes; IL-6|
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
Settore M-EDF/01 - Metodi e Didattiche delle Attivita' Motorie
Settore M-EDF/02 - Metodi e Didattiche delle Attivita' Sportive
|Data di pubblicazione:||2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1080/02640414.2013.830190|
|Appare nelle tipologie:||01 - Articolo su periodico|
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