Early detection of inflammation in neonatal calves allows early intervention, which may reduce mortality. Paraoxonase-1 (PON1) is a negative acute phase protein in humans. The aims of this study were to investigate age-related variability in serum PON1 activity and its clinical usefulness in neonatal calves. In healthy calves (n = 9), PON1 activity increased with age from 2 to 21 days of age. There was no significant increase in PON1 activity in healthy calves from days 21 to 120 (n = 15), but PON1 activity was significantly higher in adult cattle (n = 45). In sick calves, serum PON1 was significantly lower in calves <7 days of age with diarrhoea (n = 8) and in calves >28- to 120-days-old with respiratory disease (n = 8) in comparison with age matched controls (n = 20 and n = 15, respectively). These results support the role of PON1 as a negative acute phase protein in cattle.

Serum paraoxonase-1 activity in neonatal calves : age related variations and comparison between healthy and sick animals / A. Giordano, M.C. Veronesi, G. Rossi, F. Pezzia, M. Probo, L. Giori, S. Paltrinieri. - In: THE VETERINARY JOURNAL. - ISSN 1090-0233. - 197:2(2013 Aug), pp. 499-501. [10.1016/j.tvjl.2013.01.034]

Serum paraoxonase-1 activity in neonatal calves : age related variations and comparison between healthy and sick animals

A. Giordano;M.C. Veronesi;G. Rossi;M. Probo;S. Paltrinieri
2013-08

Abstract

Early detection of inflammation in neonatal calves allows early intervention, which may reduce mortality. Paraoxonase-1 (PON1) is a negative acute phase protein in humans. The aims of this study were to investigate age-related variability in serum PON1 activity and its clinical usefulness in neonatal calves. In healthy calves (n = 9), PON1 activity increased with age from 2 to 21 days of age. There was no significant increase in PON1 activity in healthy calves from days 21 to 120 (n = 15), but PON1 activity was significantly higher in adult cattle (n = 45). In sick calves, serum PON1 was significantly lower in calves <7 days of age with diarrhoea (n = 8) and in calves >28- to 120-days-old with respiratory disease (n = 8) in comparison with age matched controls (n = 20 and n = 15, respectively). These results support the role of PON1 as a negative acute phase protein in cattle.
paraoxonase-1; acute phase protein; calves; age
Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria
Settore VET/10 - Clinica Ostetrica e Ginecologia Veterinaria
THE VETERINARY JOURNAL
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/224975
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