This review is devoted to the computer aided design of drugs targeting protein-protein interactions (PPIs). General features of PPIs are discussed in the introduction, then the problems of protein interfaces druggability and design techniques application are addressed, and finally a case of active peptides design is described.
Protein-protein interactions as a drug target: A molecular modeling approach / S. Pieraccini. - In: LA CHIMICA E L'INDUSTRIA. - ISSN 0009-4315. - 95:5(2013), pp. 126-132.
Protein-protein interactions as a drug target: A molecular modeling approach
S. PieracciniPrimo
2013
Abstract
This review is devoted to the computer aided design of drugs targeting protein-protein interactions (PPIs). General features of PPIs are discussed in the introduction, then the problems of protein interfaces druggability and design techniques application are addressed, and finally a case of active peptides design is described.
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