BACKGROUND: Preterm infants are at risk for developing neurodevelopment impairments. Nutrition may play a key role in early brain development. OBJECTIVE: Aim of the study was to evaluate the effect of high protein and energy intakes during the first 6 months of corrected age on neurodevelopment in a cohort of preterm infants. DESIGN/METHODS: At term corrected age 156 preterm infants (BW <1500 g) were randomized to receive either a post-discharge formula (75 kcal and 2 g per 100 ml-G1=n 89) or a standard term formula (68 kcal and 1.4 g per 100 ml-G2: n=67) up to 6 months of corrected age. Energy and protein intakes were collected. Weight, length and head circumference were assessed a 1, 3, 6, 12 and 24 months of corrected age. Neurodevelopment was assessed at 24 months of corrected age using the Griffiths Mental Developmental Scale (DS) and related subscales. RESULTS: No difference in BW (1142 ±237 vs 1175 ±241 g) and gestational age (29,9 ±2.3 vs 29.9 ±2.1) was found between G1 and G2, respectively. G2 protein intake (g/kg/day) during the intervention period was higher than in G1 (2.8 ± 0.4 vs 2.2 ± 0.4, p<0.001) whereas no difference with regard to energy intakes was detected. Head circumference Z scores at 24 month were higher in G1 compared to G2 (-0.3 ± 1.2 vs -0.8 ± 0.9, respectively p < 0.05). After adjusting for confounding variables, protein (beta coefficients 4.45, p < 0.05) and energy (beta coefficients 0.19, p < 0.05) intakes were independently associated with locomotor subscale scores. CONCLUSIONS: After discharge each g/kg/d in protein intake and each kcal/kg/d in energy intake were associated with 4.45 point increase and with 1.9 point increase in the locomotor subscale scores, respectively. Reference: Roggero P et al. Growth and fat–free mass gain in preterm infants after discharge: a randomized controlled trial Pediatrics 2012;130:e1215-21.

Effect of High Protein and Energy Intakes on Neurodevelopmental Outcome of Very Low Birth Weight Infants / M.L. Gianni, P. Roggero, O. Amato, N. Liotto, F. Taroni, P. Piemontese, O. Picciolini, F. Mosca. ((Intervento presentato al convegno The Pediatric Academic Societies (PAS) Annual Meeting tenutosi a Washington nel 2013.

Effect of High Protein and Energy Intakes on Neurodevelopmental Outcome of Very Low Birth Weight Infants

M.L. Gianni;O. Amato;N. Liotto;F. Taroni;O. Picciolini;F. Mosca
2013

Abstract

BACKGROUND: Preterm infants are at risk for developing neurodevelopment impairments. Nutrition may play a key role in early brain development. OBJECTIVE: Aim of the study was to evaluate the effect of high protein and energy intakes during the first 6 months of corrected age on neurodevelopment in a cohort of preterm infants. DESIGN/METHODS: At term corrected age 156 preterm infants (BW <1500 g) were randomized to receive either a post-discharge formula (75 kcal and 2 g per 100 ml-G1=n 89) or a standard term formula (68 kcal and 1.4 g per 100 ml-G2: n=67) up to 6 months of corrected age. Energy and protein intakes were collected. Weight, length and head circumference were assessed a 1, 3, 6, 12 and 24 months of corrected age. Neurodevelopment was assessed at 24 months of corrected age using the Griffiths Mental Developmental Scale (DS) and related subscales. RESULTS: No difference in BW (1142 ±237 vs 1175 ±241 g) and gestational age (29,9 ±2.3 vs 29.9 ±2.1) was found between G1 and G2, respectively. G2 protein intake (g/kg/day) during the intervention period was higher than in G1 (2.8 ± 0.4 vs 2.2 ± 0.4, p<0.001) whereas no difference with regard to energy intakes was detected. Head circumference Z scores at 24 month were higher in G1 compared to G2 (-0.3 ± 1.2 vs -0.8 ± 0.9, respectively p < 0.05). After adjusting for confounding variables, protein (beta coefficients 4.45, p < 0.05) and energy (beta coefficients 0.19, p < 0.05) intakes were independently associated with locomotor subscale scores. CONCLUSIONS: After discharge each g/kg/d in protein intake and each kcal/kg/d in energy intake were associated with 4.45 point increase and with 1.9 point increase in the locomotor subscale scores, respectively. Reference: Roggero P et al. Growth and fat–free mass gain in preterm infants after discharge: a randomized controlled trial Pediatrics 2012;130:e1215-21.
Settore MED/38 - Pediatria Generale e Specialistica
Effect of High Protein and Energy Intakes on Neurodevelopmental Outcome of Very Low Birth Weight Infants / M.L. Gianni, P. Roggero, O. Amato, N. Liotto, F. Taroni, P. Piemontese, O. Picciolini, F. Mosca. ((Intervento presentato al convegno The Pediatric Academic Societies (PAS) Annual Meeting tenutosi a Washington nel 2013.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/224720
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