Ovarian cancer (OC) is the most aggressive gynaecological cancer. Understanding OC molecular pathogenesis is critical to provide novel therapeutic strategies. We aim to elucidate Notch oncogenic role in OC by focusing on its extensive crosstalk with other important pathways as CXCR4/SDF1 chemokine system whose involvement in OC development and metastasis is well recognized. The analyzed OC cell lines high levels of CXCR4 and its ligand SDF1. Treatment with DAPT, an inhibitor of Notch activity, reduced OC cell proliferation and blocked cell cycle in G0/G1 phase without affecting apoptosis. In addition, Notch withdrawal diminished CXCR4 and SDF1 expression levels and hampered SDF1-driven migration and proliferation. In conclusion, Notch deregulation might affect important features of OC such as cell growth and migration through the modulation of CXCR4/SDF1a pathway. This indicates that these intertwined pathways are promising therapeutic targets in OC.

Cooperation between Notch and CXCR4/SDF1a axis in ovarian cancer / N. Platonova, M. Colombo, E. Vigolo, L. Apicella, L. Mirandola, R. Chiaramonte. ((Intervento presentato al convegno Hallmarks of Cancer tenutosi a San Francisco nel 2012.

Cooperation between Notch and CXCR4/SDF1a axis in ovarian cancer

N. Platonova
Primo
;
M. Colombo
Secondo
;
L. Apicella;L. Mirandola
Penultimo
;
R. Chiaramonte
Ultimo
2012-10-31

Abstract

Ovarian cancer (OC) is the most aggressive gynaecological cancer. Understanding OC molecular pathogenesis is critical to provide novel therapeutic strategies. We aim to elucidate Notch oncogenic role in OC by focusing on its extensive crosstalk with other important pathways as CXCR4/SDF1 chemokine system whose involvement in OC development and metastasis is well recognized. The analyzed OC cell lines high levels of CXCR4 and its ligand SDF1. Treatment with DAPT, an inhibitor of Notch activity, reduced OC cell proliferation and blocked cell cycle in G0/G1 phase without affecting apoptosis. In addition, Notch withdrawal diminished CXCR4 and SDF1 expression levels and hampered SDF1-driven migration and proliferation. In conclusion, Notch deregulation might affect important features of OC such as cell growth and migration through the modulation of CXCR4/SDF1a pathway. This indicates that these intertwined pathways are promising therapeutic targets in OC.
Settore MED/04 - Patologia Generale
Settore MED/06 - Oncologia Medica
Settore MED/05 - Patologia Clinica
http://www.cell-symposia-hallmarksofcancer.com/
Cooperation between Notch and CXCR4/SDF1a axis in ovarian cancer / N. Platonova, M. Colombo, E. Vigolo, L. Apicella, L. Mirandola, R. Chiaramonte. ((Intervento presentato al convegno Hallmarks of Cancer tenutosi a San Francisco nel 2012.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/224696
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