The enantioselective organocatalytic reduction of trifluoromethyl aryl and alkyl ketoimines afforded the corresponding fluorinated amines with high chemical and stereochemical efficiency. The Lewis base catalyzed reaction with trichlorosilane led to chiral products with a trifluoromethyl group directly linked to the newly generated stereocenter typically in >90% yield and up to 98% e.e.

Stereoselective metal-free catalytic synthesis of chiral trifluoromethyl aryl and alkyl amines / A. Genoni, M. Benaglia, E. Massolo, S. Rossi. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 49:75(2013), pp. 8365-8367. [10.1039/c3cc43821j]

Stereoselective metal-free catalytic synthesis of chiral trifluoromethyl aryl and alkyl amines

A. Genoni;M. Benaglia;E. Massolo;S. Rossi
2013

Abstract

The enantioselective organocatalytic reduction of trifluoromethyl aryl and alkyl ketoimines afforded the corresponding fluorinated amines with high chemical and stereochemical efficiency. The Lewis base catalyzed reaction with trichlorosilane led to chiral products with a trifluoromethyl group directly linked to the newly generated stereocenter typically in >90% yield and up to 98% e.e.
enantioselective reduction; hydrogenation; trichlorosilane; imines; access; esters
Settore CHIM/06 - Chimica Organica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/224670
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