Objective: Phasic blood flow dynamics and wall shear stress (WSS) have the potential to directly modulate endothelial responses, playing an important role in the development of bypass graft occlusion. This study compares phasic blood flow velocity patterns and WSS of the left internal thoracic artery (LITA) used as a composite Y-graft (27 patients, Y-group) and as a single graft (24 patients, S-group) on the left anterior descending (LAD) coronary artery. Methods: An intravascular Doppler-tipped guide wire was used for postoperative analysis of phasic blood flow velocity. Flow velocities were recorded proximally and distally into the LITA in both groups. Digitalized spectral velocities were acquired to compute systolic peak velocity, diastolic peak velocity, and average peak velocity. The ratio of diastolic to systolic peak velocity was computed (DSVR). WSS was calculated from graft flow velocity and vessel diameter. Results: Proximal LITA in Y-group had greater average peak velocity (APV) (p = 0.000), DSVR (p = 0.026), flow volume (p = 0.000), WSS (p = 0.02), and diameter (0.019) than S-group. There were not significant differences for the distal LITA between the two groups. Conclusions: The LITA shows a marked adaptability to flow dynamics. The proximal tract of the LITA in Y-group is able to match increased flow requirements, probably through the release of endothelial vasoactive mediators. Flow velocity spectra acquired in the proximal LITA in Y-group resemble the biphasic coronary artery pattern with a clear diastolic predominance. This pattern is probably consequence of the increase of blood flow due to the lower vascular resistance of the Y-graft system and to the active dilatation of the LITA.
Flow dynamics and wall shear stress in the left internal thoracic artery : composite arterial graft versus single graft / M. Lemma, A. Innorta, M. Pettinari, A. Mangini, G. Gelpi, M. Piccaluga, P. Danna, C. Antona. - In: EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY. - ISSN 1010-7940. - 29:4(2006), pp. 473-478.
|Titolo:||Flow dynamics and wall shear stress in the left internal thoracic artery : composite arterial graft versus single graft|
INNORTA, ANDREA (Secondo)
ANTONA, CARLO (Ultimo)
|Parole Chiave:||shear stress; Y graft; composite graft; coronary artery bypass; internal mammary artery; endothelial response|
|Settore Scientifico Disciplinare:||Settore MED/23 - Chirurgia Cardiaca|
|Data di pubblicazione:||2006|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.ejcts.2006.01.035|
|Appare nelle tipologie:||01 - Articolo su periodico|