The role of the promyelocytic leukemia (PML) protein has been widely tested in many different contexts, as attested by the hundreds of papers present in the literature. In most of these studies, PML is regarded as a tumor suppressor, a notion on the whole accepted by the scientific community. In this review, we examine how the concept of tumor-suppressor gene has evolved until now and then systematically assess whether this assumption for PML is supported by unambiguous experimental evidence.
Is PML a tumor suppressor? / M. Mazza, P.G. Pelicci. - In: FRONTIERS IN ONCOLOGY. - ISSN 2234-943X. - 3:(2013), p. 00174.174. [10.3389/fonc.2013.00174]
Is PML a tumor suppressor?
M. Mazza;P.G. Pelicci
2013
Abstract
The role of the promyelocytic leukemia (PML) protein has been widely tested in many different contexts, as attested by the hundreds of papers present in the literature. In most of these studies, PML is regarded as a tumor suppressor, a notion on the whole accepted by the scientific community. In this review, we examine how the concept of tumor-suppressor gene has evolved until now and then systematically assess whether this assumption for PML is supported by unambiguous experimental evidence.
| File | Dimensione | Formato | |
|---|---|---|---|
|
Is PML a tumor suppressor?_FRONTIERS IN ONCOLOGY July 2013.pdf
accesso aperto
Tipologia:
Publisher's version/PDF
Dimensione
806.36 kB
Formato
Adobe PDF
|
806.36 kB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
