INTRODUCTION: Surgery is the mainstay of treatment for all breast sarcomas. The role of adjuvant chemotherapy and radiation therapy has not been clearly defined. The aim of this single-center retrospective study was to analyze prognostic factors, outcome, and recent advances. MATERIALS AND METHODS: Data from 203 patients with all breast sarcomas treated in a single center were collected from 1996 to 2010. Phyllodes tumors and metastatic disease at presentation were excluded from the population. Thirty-six women and 1 man were included in the analysis. Local recurrence, metastatic disease, survival, and reconstructive outcome were evaluated. RESULTS: Thirty-four patients out of 37 (91.9%) had an angiosarcoma and 3 had a stromal sarcoma (8.1%). Twenty-one patients (56.8%) had previously undergone breast radiation therapy for breast carcinoma or lymphoma. Twenty-six patients (70.3%) underwent mastectomy, 14 of whom (53.8%) with breast reconstruction. Thirty-six patients (97.3%) had free margins, 1 (2.7%) had a microscopically focally involved margin after surgery. Five patients received adjuvant chemotherapy and 6 received adjuvant radiation therapy. Median follow-up was 58 months (range, 4-146 months). Twelve sarcoma-related deaths were observed with a 5-year cumulative incidence of 43.4%. Twenty-four sarcoma-related events were observed with a 5-year cumulative incidence of 70.8%. The same figure was 49.7% in patients affected by primary sarcoma and 85.7% in patients with secondary sarcoma (P = .06). CONCLUSION: Secondary sarcomas were associated with a higher risk of events. Patients undergoing breast conservative surgery or reconstruction after mastectomy did not show a worse prognosis compared with patients undergoing mastectomy.
Sarcoma of the breast : outcome and reconstructive options / A. Toesca, G. Spitaleri, T. De Pas, E. Botteri, O. Gentilini, L. Bottiglieri, N. Rotmentsz, C. Sangalli, E. Marrazzo, E. Cassano, P. Veronesi, M. Rietjens, A. Luini. - In: CLINICAL BREAST CANCER. - ISSN 1526-8209. - 12:6(2012 Dec), pp. 438-444.
|Titolo:||Sarcoma of the breast : outcome and reconstructive options|
RIETJENS, MARIO (Penultimo)
|Parole Chiave:||Angiosarcoma; Breast reconstruction; Breast sarcoma; Primary sarcoma; Secondary sarcoma|
|Settore Scientifico Disciplinare:||Settore MED/18 - Chirurgia Generale|
Settore MED/19 - Chirurgia Plastica
|Data di pubblicazione:||dic-2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.clbc.2012.09.008|
|Appare nelle tipologie:||01 - Articolo su periodico|