Purpose: We prospectively analyzed quality of life in a cohort of patients with prostate cancer undergoing a course of hypofractionated image guided radiotherapy. Materials and Methods: Between August 2006 and January 2011, 337 patients with a median age of 73 years who had cT1-T2N0M0 prostate cancer were eligible for this prospective, longitudinal study of hypofractionated image guided radiotherapy (70.2 Gy/26 fractions) using 1 of 3 image guided radiotherapy modalities (transabdominal ultrasound, x-ray or cone beam computerized tomography) available in our radiation oncology department. Patients completed 4 questionnaires before treatment, and 6, 12 and 24 months later, including the International Index of Erectile Function-5, International Prostate Symptom Score, and EORTC (European Organization for Research and Treatment of Cancer) prostate cancer specific QLQ-PR25 and QLQ-C30. Results: Patient followup was updated to at least the last questionnaire time point. Median followup was 19 months. Significant deterioration in erectile function on the International Index of Erectile Function-5 was documented with time only in patients without androgen deprivation (p 0.0002). No change with time was observed in urinary symptom related quality of life on the QLQ-PR25 or International Prostate Symptom Score. Slight deterioration in QLQ-PR25 bowel symptom related quality of life was observed (p 0.02). Overall QLQ-C30 Global Health Status improved with time (p 0.03). On univariate analysis it significantly correlated with the maximum RTOG (Radiation Therapy Oncology Group)/EORTC urinary and bowel late toxicity scores after radiotherapy. Conclusions: The regimen of hypofractionated image guided radiotherapy with multiple imaging modalities adopted in our radiation oncology department for localized prostate cancer might be a successful strategy for dose escalation with a limited impact on different aspects of quality of life with time.
|Titolo:||Image guided hypofractionated radiotherapy and quality of life for localized prostate cancer : prospective longitudinal study in 337 patients|
|Parole Chiave:||dose fractionation; quality of life; aged; aged, 80 and over; diagnostic imaging; humans; Italy; longitudinal studies; male; middle aged; multivariate analysis; neoplasm invasiveness; neoplasm staging; patient selection; prospective studies; prostate; prostatic neoplasms; radiotherapy, image-guided; regression analysis; risk assessment; statistics, nonparametric; survival rate; treatment outcome|
|Settore Scientifico Disciplinare:||Settore MED/24 - Urologia|
Settore MED/36 - Diagnostica per Immagini e Radioterapia
|Data di pubblicazione:||giu-2013|
|Digital Object Identifier (DOI):||10.1016/j.juro.2013.01.005|
|Appare nelle tipologie:||01 - Articolo su periodico|