Radical external-beam radiotherapy (EBRT) is a standard treatment for prostate cancer (PC) patients. Despite this, the rate of intraprostatic relapses after primary EBRT is still not negligible. There is no consensus on the most appropriate management of these patients after EBRT failure. Treatment strategies after PC relapse are strongly influenced by the effective site of the tumor recurrence, and thus the instrumental evaluation with different imaging techniques becomes crucial. In cases of demonstrated intraprostatic failure, several systemic (androgen deprivation therapy) or local (salvage prostatectomy, cryotherapy, high-intensity focused ultrasound, brachytherapy, stereotactic EBRT) treatment options could be proposed and are currently delivered by clinicians with a variety of results. In this review we analyze the correct definition of intraprostatic relapse after radiotherapy, focusing on the recent developments in imaging to detect intraprostatic recurrence. Furthermore, all available salvage treatment options after a radiation therapy local failure are presented and thoroughly discussed.
Salvage therapy of intraprostatic failure after radical external-beam radiotherapy for prostate cancer : a review / F. Alongi, B. De Bari, F. Campostrini, S. Arcangeli, D.V. Matei, E. Lopci, G. Petralia, M. Bellomi, A. Chiti, S.M. Magrini, M. Scorsetti, R. Orecchia, B.A. Jereczek-Fossa. - In: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. - ISSN 1040-8428. - 88:3(2013 Dec), pp. 550-563.
Titolo: | Salvage therapy of intraprostatic failure after radical external-beam radiotherapy for prostate cancer : a review |
Autori: | ORECCHIA, ROBERTO (Penultimo) JERECZEK, BARBARA ALICJA (Ultimo) |
Parole Chiave: | brachytherapy; cryotherapy; EBRT; HIFU; hormonal therapy; intraprostatic failure; prostatectomy; salvage therapy |
Settore Scientifico Disciplinare: | Settore MED/36 - Diagnostica per Immagini e Radioterapia |
Data di pubblicazione: | dic-2013 |
Rivista: | |
Tipologia: | Article (author) |
Data ahead of print / Data di stampa: | 15-ago-2013 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.critrevonc.2013.07.009 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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