Lipases from Mucor miehei (MML) and Candida antarctica (CAL) are able to catalyze the benzoylation of the primary hydroxy group of 1.2-diols with vinyl benzoate in organic solvents. We have studied the MML-catalyzed benzoylation that proceeds with high regioselectivity and moderate enantioselectivity, whereas in the dibenzoylation reaction activity of MML and stereoselectivity of the enzymatic process is strongly influenced by steric factors.
Lipase-catalyzed selective benzoylation of 1,2-diols with vinyl benzoate in organic solvents / P. Ciuffreda, L. Alessandrini, G. Terraneo, E. Santaniello. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 14:20(2003), pp. 3197-3201. [10.1016/j.tetasy.2003.07.003]
Lipase-catalyzed selective benzoylation of 1,2-diols with vinyl benzoate in organic solvents
P. CiuffredaPrimo
;L. AlessandriniSecondo
;G. TerraneoPenultimo
;E. SantanielloUltimo
2003
Abstract
Lipases from Mucor miehei (MML) and Candida antarctica (CAL) are able to catalyze the benzoylation of the primary hydroxy group of 1.2-diols with vinyl benzoate in organic solvents. We have studied the MML-catalyzed benzoylation that proceeds with high regioselectivity and moderate enantioselectivity, whereas in the dibenzoylation reaction activity of MML and stereoselectivity of the enzymatic process is strongly influenced by steric factors.
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