We investigated the association between polyclonal serum-free light chains and prognostic biomarkers routinely used in the setting of HIV infection. For this purpose serum samples of 182 HIV-infected patients from the Italian Cohort of Antiretroviral Naive Patients foundation cohort were analysed. We found that polyclonal serum free light chains above the upper normal limit are strongly correlated in HIV-infected patients with advancing age, shorter time of undetectable HIV viremia, higher viral load and with lower CD4 cell count at sample.
Polyclonal serum-free light chains elevation in HIV-infected patients / M. Bibas, P. Lorenzini, A. Cozzi-Lepri, A. Calcagno, S. di Giambenedetto, A. Costantini, A. Castagna, V. Manfrin, A. d‟Arminio Monforte, A. Antinori, ICONA Cohort Study. - In: AIDS. - ISSN 0269-9370. - 26:16(2012 Oct 23), pp. 2107-2110. [10.1097/QAD.0b013e328358d54b]
Polyclonal serum-free light chains elevation in HIV-infected patients
A. d‟Arminio Monforte;
2012
Abstract
We investigated the association between polyclonal serum-free light chains and prognostic biomarkers routinely used in the setting of HIV infection. For this purpose serum samples of 182 HIV-infected patients from the Italian Cohort of Antiretroviral Naive Patients foundation cohort were analysed. We found that polyclonal serum free light chains above the upper normal limit are strongly correlated in HIV-infected patients with advancing age, shorter time of undetectable HIV viremia, higher viral load and with lower CD4 cell count at sample.
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