A scalable method for the preparation of 4,5-disubstituted thiazoles and imidazoles as distinct regioisomeric products using a modular flow microreactor has been devised. The process makes use of microfluidic reaction chips and packed immobilized-reagent columns to effect bifurcation of the reaction pathway.
A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor / I.R. Baxendale, S.V. Ley, C.D. Smith, L. Tamborini, A.-F. Voica. - In: JOURNAL OF COMBINATORIAL CHEMISTRY. - ISSN 1520-4766. - 10:6(2008), pp. 851-857.
A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor
L. TamboriniPenultimo
;
2008
Abstract
A scalable method for the preparation of 4,5-disubstituted thiazoles and imidazoles as distinct regioisomeric products using a modular flow microreactor has been devised. The process makes use of microfluidic reaction chips and packed immobilized-reagent columns to effect bifurcation of the reaction pathway.
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