Acute myeloid leukemia (AML) with deranged core-binding factor beta (CBFβ) is usually associated with a favorable prognosis with 50-70% of patients cured using contemporary treatments. We analyzed the prognostic significance of clinical features on 58 patients with CBFβ-AML aged ≤60 years. Increasing age was the only predictor for survival (P <0.001), with an optimal cut-point at 43 years. White blood cells (WBCs) at diagnosis emerged as an independent risk factor for relapse incidence (P = 0.017), with 1.1% increase of hazard for each 1.0 × 109 /L WBC increment. KIT mutations lacked prognostic value for survival and showed only a trend for relapse incidence (P = 0.069).
Old and new prognostic factors in acute myeloid leukemia with deranged core-binding factor beta / R. Cairoli, A. Beghini, M. Turrini, G. Bertani, G. Nadali, F. Rodeghiero, C. Castagnola, F. Lazzaroni, M. Nichelatti, F. Ferrara, G. Pizzolo, E. Pogliani, G. Rossi, G. Martinelli, E. Morra. - In: AMERICAN JOURNAL OF HEMATOLOGY. - ISSN 0361-8609. - 88:7(2013 Jul), pp. 594-600. [10.1002/ajh.23461]
Old and new prognostic factors in acute myeloid leukemia with deranged core-binding factor beta.
A. BeghiniSecondo
;M. Turrini;F. Lazzaroni;
2013
Abstract
Acute myeloid leukemia (AML) with deranged core-binding factor beta (CBFβ) is usually associated with a favorable prognosis with 50-70% of patients cured using contemporary treatments. We analyzed the prognostic significance of clinical features on 58 patients with CBFβ-AML aged ≤60 years. Increasing age was the only predictor for survival (P <0.001), with an optimal cut-point at 43 years. White blood cells (WBCs) at diagnosis emerged as an independent risk factor for relapse incidence (P = 0.017), with 1.1% increase of hazard for each 1.0 × 109 /L WBC increment. KIT mutations lacked prognostic value for survival and showed only a trend for relapse incidence (P = 0.069).File | Dimensione | Formato | |
---|---|---|---|
ajh23461.pdf
accesso aperto
Tipologia:
Publisher's version/PDF
Dimensione
179.34 kB
Formato
Adobe PDF
|
179.34 kB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.