Acute myeloid leukemia (AML) with deranged core-binding factor beta (CBFβ) is usually associated with a favorable prognosis with 50-70% of patients cured using contemporary treatments. We analyzed the prognostic significance of clinical features on 58 patients with CBFβ-AML aged ≤60 years. Increasing age was the only predictor for survival (P <0.001), with an optimal cut-point at 43 years. White blood cells (WBCs) at diagnosis emerged as an independent risk factor for relapse incidence (P = 0.017), with 1.1% increase of hazard for each 1.0 × 109 /L WBC increment. KIT mutations lacked prognostic value for survival and showed only a trend for relapse incidence (P = 0.069).

Old and new prognostic factors in acute myeloid leukemia with deranged core-binding factor beta / R. Cairoli, A. Beghini, M. Turrini, G. Bertani, G. Nadali, F. Rodeghiero, C. Castagnola, F. Lazzaroni, M. Nichelatti, F. Ferrara, G. Pizzolo, E. Pogliani, G. Rossi, G. Martinelli, E. Morra. - In: AMERICAN JOURNAL OF HEMATOLOGY. - ISSN 0361-8609. - 88:7(2013 Jul), pp. 594-600. [10.1002/ajh.23461]

Old and new prognostic factors in acute myeloid leukemia with deranged core-binding factor beta.

A. Beghini
Secondo
;
M. Turrini;F. Lazzaroni;
2013

Abstract

Acute myeloid leukemia (AML) with deranged core-binding factor beta (CBFβ) is usually associated with a favorable prognosis with 50-70% of patients cured using contemporary treatments. We analyzed the prognostic significance of clinical features on 58 patients with CBFβ-AML aged ≤60 years. Increasing age was the only predictor for survival (P <0.001), with an optimal cut-point at 43 years. White blood cells (WBCs) at diagnosis emerged as an independent risk factor for relapse incidence (P = 0.017), with 1.1% increase of hazard for each 1.0 × 109 /L WBC increment. KIT mutations lacked prognostic value for survival and showed only a trend for relapse incidence (P = 0.069).
Settore MED/03 - Genetica Medica
Settore MED/15 - Malattie del Sangue
lug-2013
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/222285
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