The procedures utilized for the synthesis of vicinal diaryl-substituted 1H-imidazoles, and the biological properties of these compounds are discussed. Several interesting procedures for the synthesis of 1,2-diaryl-1H-imidazoles involve the elaboration of imidazole derivatives instead of the construction of the heteroaromatic ring. The synthesis strategy of 1,5-diaryl-1H-imidazoles, was employed to prepare a large variety of pharmacologically interesting compounds that include COX-2-selective inhibitors. The mitogen-activated protein (MAP) kinases are able to mediate intracellular signal transduction and participate in a number of physiological as well as pathophysiological cellular processes including cell growth, differentiation, and apoptosis. 4,5-Diaryl-1H-imidazoles have been identified as a class of compounds, which include derivatives showing considerable antimicrobial activity against bacteria, yeast, and fungi.
Synthesis and biological activity of vicinal diaryl-substituted 1H-imidazoles / F. Bellina, S. Cauteruccio, R. Rossi. - In: TETRAHEDRON. - ISSN 0040-4020. - 63:22(2007), pp. 4571-4624.
Synthesis and biological activity of vicinal diaryl-substituted 1H-imidazoles
S. Cauteruccio;
2007
Abstract
The procedures utilized for the synthesis of vicinal diaryl-substituted 1H-imidazoles, and the biological properties of these compounds are discussed. Several interesting procedures for the synthesis of 1,2-diaryl-1H-imidazoles involve the elaboration of imidazole derivatives instead of the construction of the heteroaromatic ring. The synthesis strategy of 1,5-diaryl-1H-imidazoles, was employed to prepare a large variety of pharmacologically interesting compounds that include COX-2-selective inhibitors. The mitogen-activated protein (MAP) kinases are able to mediate intracellular signal transduction and participate in a number of physiological as well as pathophysiological cellular processes including cell growth, differentiation, and apoptosis. 4,5-Diaryl-1H-imidazoles have been identified as a class of compounds, which include derivatives showing considerable antimicrobial activity against bacteria, yeast, and fungi.Pubblicazioni consigliate
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