The procedures utilized for the synthesis of vicinal diaryl-substituted 1H-imidazoles, and the biological properties of these compounds are discussed. Several interesting procedures for the synthesis of 1,2-diaryl-1H-imidazoles involve the elaboration of imidazole derivatives instead of the construction of the heteroaromatic ring. The synthesis strategy of 1,5-diaryl-1H-imidazoles, was employed to prepare a large variety of pharmacologically interesting compounds that include COX-2-selective inhibitors. The mitogen-activated protein (MAP) kinases are able to mediate intracellular signal transduction and participate in a number of physiological as well as pathophysiological cellular processes including cell growth, differentiation, and apoptosis. 4,5-Diaryl-1H-imidazoles have been identified as a class of compounds, which include derivatives showing considerable antimicrobial activity against bacteria, yeast, and fungi.
|Titolo:||Synthesis and biological activity of vicinal diaryl-substituted 1H-imidazoles|
|Parole Chiave:||Imidazoles ; Synthesis ; Selectivity ; Bioactivity ; Enzyme inhibitors|
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Data di pubblicazione:||2007|
|Digital Object Identifier (DOI):||10.1016/j.tet.2007.02.075|
|Appare nelle tipologie:||01 - Articolo su periodico|