Albumin is the major plasma protein and its determination is used for the prognostic assessment of several diseases. Clinical guidelines call for monitoring of serum albumin with specific target cut-offs that are independent of the assay used. This requires accurate and equivalent results among different commercially available methods (i.e., result standardization) through a consistent definition and application of a reference measurement system. This should be associated with the definition of measurement uncertainty goals based on medical relevance of serum albumin to make results reliable for patient management. In this paper, we show that, in the current situation, if one applies analytical goals for serumalbuminmeasurement derived fromits biologic variation, the uncertainty budget derived from each step of the albumin traceability chain is probably too high to fulfil established quality levels for albumin measurement and to guarantee the accuracy needed for clinical usefulness of the test. The situation is further worsened if non-specific colorimetric methods are used for albumin measurement as they represent an additional random source of uncertainty.

Serum albumin: accuracy and clinical use / C.J. Infusino, M. Panteghini. - In: CLINICA CHIMICA ACTA. - ISSN 0009-8981. - 419:(2013), pp. 15-18. [10.1016/j.cca.2013.01.005]

Serum albumin: accuracy and clinical use

C.J. Infusino
Primo
;
M. Panteghini
Ultimo
2013

Abstract

Albumin is the major plasma protein and its determination is used for the prognostic assessment of several diseases. Clinical guidelines call for monitoring of serum albumin with specific target cut-offs that are independent of the assay used. This requires accurate and equivalent results among different commercially available methods (i.e., result standardization) through a consistent definition and application of a reference measurement system. This should be associated with the definition of measurement uncertainty goals based on medical relevance of serum albumin to make results reliable for patient management. In this paper, we show that, in the current situation, if one applies analytical goals for serumalbuminmeasurement derived fromits biologic variation, the uncertainty budget derived from each step of the albumin traceability chain is probably too high to fulfil established quality levels for albumin measurement and to guarantee the accuracy needed for clinical usefulness of the test. The situation is further worsened if non-specific colorimetric methods are used for albumin measurement as they represent an additional random source of uncertainty.
English
Accuracy; Albumin; Standardization
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
Articolo
Comitato scientifico
2013
Elsevier
419
15
18
4
Pubblicato
Periodico con rilevanza internazionale
info:eu-repo/semantics/article
Serum albumin: accuracy and clinical use / C.J. Infusino, M. Panteghini. - In: CLINICA CHIMICA ACTA. - ISSN 0009-8981. - 419:(2013), pp. 15-18. [10.1016/j.cca.2013.01.005]
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Prodotti della ricerca::01 - Articolo su periodico
2
262
Article (author)
Periodico con Impact Factor
C.J. Infusino, M. Panteghini
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/221816
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