Some biological properties of Bombyx mori sericins from twenty strains were investigated, fourteen fed with artificial diet, two with fresh mulberry leaves and four with both diets. Sericin exhibited ROS-scavenging, anti-tyrosinase and anti-elastase properties, the strain significantly influenced these properties, while diet only influenced the anti-tyrosinase activity. Sericins were clustered into 5 groups and one sericin from each group was further studied: sericins showed anti-proliferative activity on in vitro stimulated peripheral blood mononuclear cells; some strains decreased in vitro secretion of IFNγ, while no effects were observed on TNFα and IL10 release. Therefore, a mixture of sericins extracted from the most promising strains may be useful for dermatological and cosmetic use.
|Titolo:||Sericine exhibit ROS-scavenging, anti-tyrosinase, anti-elestase, and in vitro immunomodulatory activities|
|Parole Chiave:||Anti-elastase activity; Anti-IFNγ activity; Anti-proliferative activity; Anti-tyrosinase activity; ROS-scavenging activity; Sericin|
|Settore Scientifico Disciplinare:||Settore VET/02 - Fisiologia Veterinaria|
|Data di pubblicazione:||27-mar-2013|
|Digital Object Identifier (DOI):||10.1016/j.ijbiomac.2013.03.054|
|Appare nelle tipologie:||01 - Articolo su periodico|