Chronic kidney disease mineral bone disorders (CKD-MBD) encompass laboratory, vascular and bone abnormalities that might portend a poor prognosis in CKD. In spite of a great effort in elucidating the CKD-MBD natural history and pathogenesis, the underlying mechanisms are still largely unknown. However, a deficit in vitamin D is commonly reported as one of the first steps in CKD-MBD, and numerous epidemiological studies have associated serum vitamin D levels with different markers of cardiovascular disease and the risk of death in different populations. We herein summarize current evidence that links vitamin D deficiency to an adverse outcome and the results of the most recent clinical trials that have investigated the impact of paricalcitol supplementation on hard outcome in CKD patients.

Paricalcitol and Cardiorenal Outcome : From the IMPACT Study to Clinical Practice / A. Bellasi, A. Galassi, P. Salvi, M. Cozzolino. - In: BLOOD PURIFICATION. - ISSN 0253-5068. - 36:1(2013 May), pp. 12-16.

Paricalcitol and Cardiorenal Outcome : From the IMPACT Study to Clinical Practice

A. Bellasi
Primo
;
A. Galassi
Secondo
;
M. Cozzolino
Ultimo
2013-05

Abstract

Chronic kidney disease mineral bone disorders (CKD-MBD) encompass laboratory, vascular and bone abnormalities that might portend a poor prognosis in CKD. In spite of a great effort in elucidating the CKD-MBD natural history and pathogenesis, the underlying mechanisms are still largely unknown. However, a deficit in vitamin D is commonly reported as one of the first steps in CKD-MBD, and numerous epidemiological studies have associated serum vitamin D levels with different markers of cardiovascular disease and the risk of death in different populations. We herein summarize current evidence that links vitamin D deficiency to an adverse outcome and the results of the most recent clinical trials that have investigated the impact of paricalcitol supplementation on hard outcome in CKD patients.
Cardiovascular risk factors; Chronic kidney disease mineral bone disorder; Surrogate outcome; Survival; Vitamin D
Settore MED/14 - Nefrologia
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/221633
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