Tendon injuries represent even today a challenge as repair may be exceedingly slow and incomplete. Regenerative medicine and stem cell technology have shown to be of great promise. Here, we will review the current knowledge on the mechanisms of the regenerative potential of mesenchymal stem cells (MSCs) obtained from different sources (bone marrow, fat, cord blood, placenta). More specifically, we will devote attention to the current use of MSCs that have been used experimentally and in limited numbers of clinical cases for the surgical treatment of subchondral-bone cysts, bone-fracture repair and cartilage repair. Based on the recently emerging role in regenerative mechanisms of soluble factors and of extracellular vesicles, we will discuss the potential of non-cellular therapies in horse tendon injuries.
The role of microvesicles derived from mesenchymal stem cells in tissue regeneration; a dream for tendon repair? / C. Tetta, A. Lange Consiglio, S. Bruno, E. Tetta, E. Gatti, M. Dobreva, F. Cremonesi, G. Camussi. - In: M.L.T.J. MUSCLES, LIGAMENTS AND TENDONS JOURNAL. - ISSN 2240-4554. - 2:3(2012 Oct 16), pp. 212-221.
The role of microvesicles derived from mesenchymal stem cells in tissue regeneration; a dream for tendon repair?
A. Lange Consiglio;F. Cremonesi;
2012
Abstract
Tendon injuries represent even today a challenge as repair may be exceedingly slow and incomplete. Regenerative medicine and stem cell technology have shown to be of great promise. Here, we will review the current knowledge on the mechanisms of the regenerative potential of mesenchymal stem cells (MSCs) obtained from different sources (bone marrow, fat, cord blood, placenta). More specifically, we will devote attention to the current use of MSCs that have been used experimentally and in limited numbers of clinical cases for the surgical treatment of subchondral-bone cysts, bone-fracture repair and cartilage repair. Based on the recently emerging role in regenerative mechanisms of soluble factors and of extracellular vesicles, we will discuss the potential of non-cellular therapies in horse tendon injuries.Pubblicazioni consigliate
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